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Etv1 ETS variant transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362733, updated on 13-Apr-2024

Summary

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Official Symbol
Etv1provided by RGD
Official Full Name
ETS variant transcription factor 1provided by RGD
Primary source
RGD:1312007
See related
Ensembl:ENSRNOG00000006867 AllianceGenome:RGD:1312007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including axon guidance; mechanosensory behavior; and positive regulation of transcription, DNA-templated. Predicted to be active in nucleus. Orthologous to human ETV1 (ETS variant transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 239.6), Adrenal (RPKM 84.2) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Etv1 in Genome Data Viewer
Location:
6q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (61316836..61408985)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (55590149..55681784)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (58467215..58558640)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, beta Neighboring gene uncharacterized LOC134479368 Neighboring gene phosphatidylethanolamine binding protein 1, pseudogene 2 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 9 Neighboring gene uncharacterized LOC120103524

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes. Shekhar A, et al. Sci Rep, 2018 Jul 2. PMID 29967479, Free PMC Article
  2. Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis. Yang L, et al. Biol Reprod, 2006 Apr. PMID 16394217
  3. Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter. Pastorcic M, et al. Brain Res Mol Brain Res, 2003 May 12. PMID 12750007
  4. Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site. Firlej V, et al. J Biol Chem, 2005 Jan 14. PMID 15466854
  5. ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Arber S, et al. Cell, 2000 May 26. PMID 10850491

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mechanosensory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscle organ development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ETS translocation variant 1
Names
ets variant gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108709.3 → NP_001102179.2  ETS translocation variant 1 isoform b

    See identical proteins and their annotated locations for NP_001102179.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    BC168860, BQ195622, JAXUCZ010000006
    UniProtKB/TrEMBL
    B5DEZ2
    Related
    ENSRNOP00000059718.1, ENSRNOT00000065396.4
    Conserved Domains (2) summary
    smart00413
    Location:311 → 395
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:1 → 310
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  2. NM_001163156.3 → NP_001156628.1  ETS translocation variant 1 isoform a

    See identical proteins and their annotated locations for NP_001156628.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC168860, BQ195622, CB547717, CB718897, JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2JTM3, B5DEZ2
    Conserved Domains (2) summary
    smart00413
    Location:334 → 418
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:2 → 333
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    61316836..61408985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262098.1 → XP_063118168.1  ETS translocation variant 1 isoform X2

  2. XM_063262097.1 → XP_063118167.1  ETS translocation variant 1 isoform X2

  3. XM_008764648.4 → XP_008762870.1  ETS translocation variant 1 isoform X4

    See identical proteins and their annotated locations for XP_008762870.1

    UniProtKB/TrEMBL
    B5DEZ2
    Conserved Domains (2) summary
    smart00413
    Location:311 → 395
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:1 → 310
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  4. XM_063262096.1 → XP_063118166.1  ETS translocation variant 1 isoform X1

  5. XM_008764647.3 → XP_008762869.1  ETS translocation variant 1 isoform X3

    Conserved Domains (2) summary
    smart00413
    Location:324 → 408
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:28 → 323
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  6. XM_063262100.1 → XP_063118170.1  ETS translocation variant 1 isoform X6

  7. XM_063262099.1 → XP_063118169.1  ETS translocation variant 1 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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