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Dmac2l distal membrane arm assembly component 2 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 362749, updated on 2-Nov-2024

Summary

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Official Symbol
Dmac2lprovided by RGD
Official Full Name
distal membrane arm assembly component 2 likeprovided by RGD
Primary source
RGD:1359208
See related
EnsemblRapid:ENSRNOG00000004893 AllianceGenome:RGD:1359208
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp5s
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in ATP biosynthetic process and proton transmembrane transport. Predicted to be located in mitochondrion. Predicted to be part of proton-transporting ATP synthase complex, coupling factor F(o). Predicted to be active in cytoplasm. Orthologous to human DMAC2L (distal membrane arm assembly component 2 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 109.1), Heart (RPKM 94.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dmac2l in Genome Data Viewer
Location:
6q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93941605..93959932)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88205580..88223934)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92057782..92076022)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene chloride intracellular channel protein 4 pseudogene Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene uncharacterized LOC102548655 Neighboring gene cyclin dependent kinase like 1 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase. Sanadi DR, et al. Proc Natl Acad Sci U S A, 1984 Mar. PMID 6143319, Free PMC Article
  2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94488

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase subunit s, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP synthase-coupling factor B
Factor B
distal membrane arm assembly complex 2 like
distal membrane arm assembly complex 2-like protein
mitochondrial ATP synthase regulatory component factor B
NP_001007750.1
XP_006240236.1
XP_006240237.1
XP_006240238.1
XP_038968432.1
XP_038968433.1
XP_063118186.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007749.1 → NP_001007750.1  ATP synthase subunit s, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001007750.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083655
    UniProtKB/Swiss-Prot
    Q5XIM4
    UniProtKB/TrEMBL
    A6HBX3
    Related
    ENSRNOP00000006509.4, ENSRNOT00000006509.7
    Conserved Domains (2) summary
    cd09293
    Location:97 → 166
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:111 → 139
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    93941605..93959932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240176.5 → XP_006240238.1  ATP synthase subunit s, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006240238.1

    UniProtKB/Swiss-Prot
    Q5XIM4
    UniProtKB/TrEMBL
    A6HBX3
    Related
    ENSRNOP00000101455.1, ENSRNOT00000132134.1
    Conserved Domains (2) summary
    cd09293
    Location:97 → 166
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:111 → 139
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. XM_006240175.5 → XP_006240237.1  ATP synthase subunit s, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006240237.1

    UniProtKB/Swiss-Prot
    Q5XIM4
    UniProtKB/TrEMBL
    A6HBX3
    Conserved Domains (2) summary
    cd09293
    Location:97 → 166
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:111 → 139
    LRR_AMN1; leucine-rich repeat [structural motif]

  3. XM_063262116.1 → XP_063118186.1  ATP synthase subunit s, mitochondrial isoform X2

  4. XM_006240174.5 → XP_006240236.1  ATP synthase subunit s, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006240236.1

    UniProtKB/Swiss-Prot
    Q5XIM4
    UniProtKB/TrEMBL
    A6HBX3
    Conserved Domains (2) summary
    cd09293
    Location:97 → 166
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:111 → 139
    LRR_AMN1; leucine-rich repeat [structural motif]

  5. XM_039112504.2 → XP_038968432.1  ATP synthase subunit s, mitochondrial isoform X3

    Conserved Domains (2) summary
    cd09293
    Location:5 → 69
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:15 → 42
    LRR_AMN1; leucine-rich repeat [structural motif]

  6. XM_039112505.2 → XP_038968433.1  ATP synthase subunit s, mitochondrial isoform X3

    Conserved Domains (2) summary
    cd09293
    Location:5 → 69
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:15 → 42
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIM4.1 GenPept UniProtKB/Swiss-Prot:Q5XIM4

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