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Pigh phosphatidylinositol glycan anchor biosynthesis, class H [ Rattus norvegicus (Norway rat) ]

Gene ID: 362756, updated on 17-Aug-2024

Summary

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Official Symbol
Pighprovided by RGD
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Hprovided by RGD
Primary source
RGD:1311438
See related
EnsemblRapid:ENSRNOG00000010914 AllianceGenome:RGD:1311438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be integral component of membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Orthologous to human PIGH (phosphatidylinositol glycan anchor biosynthesis class H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 59.0), Brain (RPKM 56.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pigh in Genome Data Viewer
Location:
6q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (103601369..103630214, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (97874903..97897188, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (102258621..102272826, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547797 Neighboring gene transmembrane protein 229B Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H1 Neighboring gene branched chain ketoacid dehydrogenase kinase, pseudogene 1 Neighboring gene arginase 2 Neighboring gene vesicle transport through interaction with t-SNAREs 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe R, et al. EMBO J, 2000 Aug 15. PMID 10944123, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit H
Names
phosphatidylinositol glycan, class H
NP_001102184.1
NP_001388291.1
XP_017449717.1
XP_063118187.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108714.2 → NP_001102184.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform 1

    See identical proteins and their annotated locations for NP_001102184.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6ALA7, A6HCG2, D4A0Z0
    Related
    ENSRNOP00000014775.3, ENSRNOT00000014775.6
    Conserved Domains (1) summary
    pfam10181
    Location:89 → 158
    PIG-H; GPI-GlcNAc transferase complex, PIG-H component

  2. NM_001401362.1 → NP_001388291.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RNA

  1. NR_190558.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    103601369..103630214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594228.3 → XP_017449717.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALA7

  2. XM_063262117.1 → XP_063118187.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform X2

RNA

  1. XR_010052119.1 RNA Sequence

  2. XR_010052120.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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