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Dglucy D-glutamate cyclase [ Rattus norvegicus (Norway rat) ]

Gene ID: 362769, updated on 2-Nov-2024

Summary

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Official Symbol
Dglucyprovided by RGD
Official Full Name
D-glutamate cyclaseprovided by RGD
Primary source
RGD:1311756
See related
EnsemblRapid:ENSRNOG00000004442 AllianceGenome:RGD:1311756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311756
Summary
Predicted to enable D-glutamate cyclase activity. Predicted to be involved in glutamate metabolic process. Predicted to be located in mitochondrial matrix. Orthologous to human DGLUCY (D-glutamate cyclase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 117.9), Adrenal (RPKM 56.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dglucy in Genome Data Viewer
Location:
6q32
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (125785075..125860496)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (120055480..120130910)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (124786164..124870244)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase A5 Neighboring gene polycomb group ring finger 5 like 1 Neighboring gene uncharacterized LOC134479467 Neighboring gene uncharacterized LOC120103602 Neighboring gene G protein-coupled receptor 68 Neighboring gene coiled-coil domain containing 88C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. (D)-Glutamate is metabolized in the heart mitochondria. Ariyoshi M, et al. Sci Rep, 2017 Mar 7. PMID 28266638, Free PMC Article
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-glutamate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-glutamate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glutamate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
D-glutamate cyclase, mitochondrial
Names
UPF0317 protein C14orf159 homolog, mitochondrial
NP_001167028.1
XP_006240503.1
XP_006240504.1
XP_017449723.1
XP_038968459.1
XP_038968460.1
XP_038968461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173557.1 → NP_001167028.1  D-glutamate cyclase, mitochondrial

    See identical proteins and their annotated locations for NP_001167028.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5ZU77
    Conserved Domains (2) summary
    pfam07286
    Location:116 → 256
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:300 → 610
    DUF4392; Domain of unknown function (DUF4392)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    125785075..125860496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240441.5 → XP_006240503.1  D-glutamate cyclase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006240503.1

    UniProtKB/TrEMBL
    A0A8I5ZU77
    Related
    ENSRNOP00000112030.1, ENSRNOT00000126596.1
    Conserved Domains (2) summary
    pfam07286
    Location:116 → 256
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:300 → 610
    DUF4392; Domain of unknown function (DUF4392)

  2. XM_039112532.2 → XP_038968460.1  D-glutamate cyclase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZU77
    Conserved Domains (2) summary
    pfam07286
    Location:116 → 256
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:300 → 610
    DUF4392; Domain of unknown function (DUF4392)

  3. XM_006240442.4 → XP_006240504.1  D-glutamate cyclase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006240504.1

    UniProtKB/TrEMBL
    A0A8I5ZU77
    Conserved Domains (2) summary
    pfam07286
    Location:116 → 256
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:300 → 610
    DUF4392; Domain of unknown function (DUF4392)

  4. XM_039112531.2 → XP_038968459.1  D-glutamate cyclase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZU77
    Related
    ENSRNOP00000082039.2, ENSRNOT00000117375.2
    Conserved Domains (2) summary
    pfam07286
    Location:116 → 256
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:300 → 610
    DUF4392; Domain of unknown function (DUF4392)

  5. XM_017594234.2 → XP_017449723.1  D-glutamate cyclase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZU77, D4A9W3
    Related
    ENSRNOP00000005903.6, ENSRNOT00000005903.9
    Conserved Domains (2) summary
    pfam07286
    Location:130 → 270
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:314 → 624
    DUF4392; Domain of unknown function (DUF4392)

  6. XM_039112533.2 → XP_038968461.1  D-glutamate cyclase, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZU77
    Conserved Domains (2) summary
    pfam07286
    Location:2 → 142
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:186 → 496
    DUF4392; Domain of unknown function (DUF4392)
Nucleotide Protein Strain
Heading Accession and Version

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