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Btbd7 BTB domain containing 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362772, updated on 17-Aug-2024

Summary

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Official Symbol
Btbd7provided by RGD
Official Full Name
BTB domain containing 7provided by RGD
Primary source
RGD:1306262
See related
EnsemblRapid:ENSRNOG00000008598 AllianceGenome:RGD:1306262
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in regulation of branching involved in salivary gland morphogenesis. Predicted to be located in nucleus. Orthologous to human BTBD7 (BTB domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 160.6), Adrenal (RPKM 124.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127685185..127774947, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121920365..122010114, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126658398..126748497, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene lysosomal enzyme trafficking factor Neighboring gene GON7 subunit of KEOPS complex Neighboring gene nuclear nucleic acid-binding protein C1D-like Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 Neighboring gene cytochrome c oxidase subunit 8C Neighboring gene unc-79 homolog, NALCN channel complex subunit Neighboring gene enolase 1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FUP1, a gene associated with hepatocellular carcinoma, stimulates NIH3T3 cell proliferation and tumor formation in nude mice. Pan W, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527404
  2. Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Onodera T, et al. Science, 2010 Jul 30. PMID 20671187, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in morphogenesis of a branching epithelium IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of branching involved in salivary gland morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein 7
Names
BTB (POZ) domain containing 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108720.1 → NP_001102190.1  BTB/POZ domain-containing protein 7

    See identical proteins and their annotated locations for NP_001102190.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473982
    UniProtKB/TrEMBL
    A6JEL7, D3ZCW2
    Related
    ENSRNOP00000062323.2, ENSRNOT00000064914.5
    Conserved Domains (4) summary
    smart00225
    Location:268 → 397
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:410 → 488
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:134 → 235
    BTB; BTB/POZ domain
    cl02518
    Location:269 → 393
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    127685185..127774947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764818.4 → XP_008763040.1  BTB/POZ domain-containing protein 7 isoform X1

    See identical proteins and their annotated locations for XP_008763040.1

    UniProtKB/TrEMBL
    A0A0G2K9E3
    Related
    ENSRNOP00000074965.1, ENSRNOT00000081127.3
    Conserved Domains (4) summary
    smart00225
    Location:268 → 397
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:410 → 488
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:134 → 235
    BTB; BTB/POZ domain
    cl02518
    Location:269 → 393
    BTB; BTB/POZ domain

  2. XM_008764819.4 → XP_008763041.1  BTB/POZ domain-containing protein 7 isoform X1

    See identical proteins and their annotated locations for XP_008763041.1

    UniProtKB/TrEMBL
    A0A0G2K9E3
    Conserved Domains (4) summary
    smart00225
    Location:268 → 397
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:410 → 488
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:134 → 235
    BTB; BTB/POZ domain
    cl02518
    Location:269 → 393
    BTB; BTB/POZ domain

  3. XM_008764821.4 → XP_008763043.1  BTB/POZ domain-containing protein 7 isoform X2

    Conserved Domains (3) summary
    smart00225
    Location:143 → 230
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:134 → 235
    BTB; BTB/POZ domain
    cl02518
    Location:269 → 340
    BTB; BTB/POZ domain
Nucleotide Protein Strain
Heading Accession and Version

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