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Glrx5 glutaredoxin 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362776, updated on 2-Nov-2024

Summary

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Official Symbol
Glrx5provided by RGD
Official Full Name
glutaredoxin 5provided by RGD
Primary source
RGD:1308383
See related
EnsemblRapid:ENSRNOG00000004206 AllianceGenome:RGD:1308383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308383
Summary
Predicted to be involved in [2Fe-2S] cluster assembly; protein maturation by [2Fe-2S] cluster transfer; and protein maturation by [4Fe-4S] cluster transfer. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Orthologous to human GLRX5 (glutaredoxin 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 295.3), Heart (RPKM 287.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Glrx5 in Genome Data Viewer
Location:
6q32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (129752902..129763278)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (123988461..123998545)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (128750503..128760880)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103610 Neighboring gene ribosomal protein L6, pseudogene 1 Neighboring gene uncharacterized LOC134479255 Neighboring gene uncharacterized LOC100912332 Neighboring gene small Cajal body-specific RNA 13 Neighboring gene uncharacterized LOC134479469 Neighboring gene Tcl1 family Akt coactivator A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. Ye H, et al. J Clin Invest, 2010 May. PMID 20364084, Free PMC Article
  2. Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5. Baker PR 2nd, et al. Brain, 2014 Feb. PMID 24334290, Free PMC Article
  3. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, et al. Biochim Biophys Acta, 2011 Jan. PMID 20620191
  4. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in [2Fe-2S] cluster assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein maturation by [2Fe-2S] cluster transfer ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation by [4Fe-4S] cluster transfer ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
part_of iron-sulfur cluster assembly complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutaredoxin-related protein 5, mitochondrial
Names
glutaredoxin 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108722.2 → NP_001102192.1  glutaredoxin-related protein 5, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001102192.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6JES1
    Conserved Domains (1) summary
    cd03028
    Location:41 → 131
    GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

  2. NM_001429150.1 → NP_001416079.1  glutaredoxin-related protein 5, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    129752902..129763278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262127.1 → XP_063118197.1  glutaredoxin-related protein 5, mitochondrial isoform X1

    Related
    ENSRNOP00000005781.5, ENSRNOT00000005781.7
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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