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Atp6v1c2 ATPase H+ transporting V1 subunit C2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362802, updated on 14-Nov-2024

Summary

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Official Symbol
Atp6v1c2provided by RGD
Official Full Name
ATPase H+ transporting V1 subunit C2provided by RGD
Primary source
RGD:1359430
See related
EnsemblRapid:ENSRNOG00000050553 AllianceGenome:RGD:1359430
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in positive regulation of Wnt signaling pathway. Predicted to act upstream of or within proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Orthologous to human ATP6V1C2 (ATPase H+ transporting V1 subunit C2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 207.5), Kidney (RPKM 81.2) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp6v1c2 in Genome Data Viewer
Location:
6q16
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (45809269..45872914, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (40080545..40144199, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (42585452..42632289, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel modifier subfamily F member 1 Neighboring gene protein disulfide isomerase family A, member 6 Neighboring gene nucleolar protein 10 Neighboring gene craniofacial development protein 1 like 1 Neighboring gene proteasome activator subunit 3, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential expression of a V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes. Feng NH, et al. J Biomed Sci, 2005 Dec. PMID 16283434
  2. Expression, purification and characterization of isoforms of peripheral stalk subunits of human V-ATPase. Rahman S, et al. Protein Expr Purif, 2011 Aug. PMID 21356312
  3. Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung. Sun-Wada GH, et al. J Biol Chem, 2003 Nov 7. PMID 12947086
  4. Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Cruciat CM, et al. Science, 2010 Jan 22. PMID 20093472
  5. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Sun-Wada GH, et al. Gene, 2003 Jan 2. PMID 12527205

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes
    Title: Differential expression of a V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit C 2
Names
ATPase, H+ transporting, V1 subunit C
ATPase, H+ transporting, lysosomal V1 subunit C2
V-ATPase subunit C 2
vacuolar H+ ATPase C2
vacuolar proton pump subunit C 2
NP_001014221.1
XP_017449730.2
XP_038968527.1
XP_038968528.1
XP_038968532.1
XP_038968535.1
XP_063118235.1
XP_063118236.1
XP_063118237.1
XP_063118238.1
XP_063118239.1
XP_063118240.1
XP_063118241.1
XP_063118242.1
XP_063118243.1
XP_063118244.1
XP_063118245.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014199.1 → NP_001014221.1  V-type proton ATPase subunit C 2

    See identical proteins and their annotated locations for NP_001014221.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079083
    UniProtKB/Swiss-Prot
    Q53B80, Q6AYE4
    UniProtKB/TrEMBL
    A0A0G2JZN3
    Related
    ENSRNOP00000066981.3, ENSRNOT00000071977.4
    Conserved Domains (2) summary
    cd14785
    Location:55 → 75
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 415
    V-ATPase_C; V-ATPase subunit C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    45809269..45872914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262173.1 → XP_063118243.1  V-type proton ATPase subunit C 2 isoform X4

    Related
    ENSRNOP00000093823.1, ENSRNOT00000099858.2

  2. XM_063262171.1 → XP_063118241.1  V-type proton ATPase subunit C 2 isoform X3

  3. XM_039112600.2 → XP_038968528.1  V-type proton ATPase subunit C 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZN3
    Conserved Domains (2) summary
    cd14785
    Location:55 → 98
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 438
    V-ATPase_C; V-ATPase subunit C

  4. XM_039112604.2 → XP_038968532.1  V-type proton ATPase subunit C 2 isoform X2

    UniProtKB/Swiss-Prot
    Q53B80, Q6AYE4
    UniProtKB/TrEMBL
    A0A0G2JZN3
    Conserved Domains (2) summary
    cd14785
    Location:55 → 75
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 415
    V-ATPase_C; V-ATPase subunit C

  5. XM_039112599.2 → XP_038968527.1  V-type proton ATPase subunit C 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZN3
    Conserved Domains (2) summary
    cd14785
    Location:55 → 98
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 438
    V-ATPase_C; V-ATPase subunit C

  6. XM_063262167.1 → XP_063118237.1  V-type proton ATPase subunit C 2 isoform X2

    UniProtKB/Swiss-Prot
    Q53B80, Q6AYE4

  7. XM_063262174.1 → XP_063118244.1  V-type proton ATPase subunit C 2 isoform X4

  8. XM_063262165.1 → XP_063118235.1  V-type proton ATPase subunit C 2 isoform X1

  9. XM_063262170.1 → XP_063118240.1  V-type proton ATPase subunit C 2 isoform X3

  10. XM_063262169.1 → XP_063118239.1  V-type proton ATPase subunit C 2 isoform X2

    UniProtKB/Swiss-Prot
    Q53B80, Q6AYE4

  11. XM_063262175.1 → XP_063118245.1  V-type proton ATPase subunit C 2 isoform X4

  12. XM_063262172.1 → XP_063118242.1  V-type proton ATPase subunit C 2 isoform X4

  13. XM_063262166.1 → XP_063118236.1  V-type proton ATPase subunit C 2 isoform X2

    UniProtKB/Swiss-Prot
    Q53B80, Q6AYE4

  14. XM_017594241.3 → XP_017449730.2  V-type proton ATPase subunit C 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZN3
    Conserved Domains (2) summary
    cd14785
    Location:55 → 98
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 438
    V-ATPase_C; V-ATPase subunit C

  15. XM_063262168.1 → XP_063118238.1  V-type proton ATPase subunit C 2 isoform X2

    UniProtKB/Swiss-Prot
    Q53B80, Q6AYE4

  16. XM_039112607.2 → XP_038968535.1  V-type proton ATPase subunit C 2 isoform X5

    UniProtKB/TrEMBL
    M0RBN8
    Conserved Domains (2) summary
    cd14785
    Location:76 → 102
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:22 → 371
    V-ATPase_C; V-ATPase subunit C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYE4.1 GenPept UniProtKB/Swiss-Prot:Q6AYE4

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