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Rnf41 ring finger protein 41 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362814, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf41provided by RGD
Official Full Name
ring finger protein 41provided by RGD
Primary source
RGD:1309557
See related
EnsemblRapid:ENSRNOG00000086706 AllianceGenome:RGD:1309557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including extrinsic apoptotic signaling pathway; positive regulation of reactive oxygen species metabolic process; and protein autoubiquitination. Predicted to act upstream of or within several processes, including negative regulation of mitophagy; regulation of hemopoiesis; and regulation of intracellular signal transduction. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum tubular network. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 159.5), Adrenal (RPKM 132.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf41 in Genome Data Viewer
Location:
7q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1422651..1461700)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (838160..876869)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2827242..2854230)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 52 Neighboring gene solute carrier family 39 member 5 Neighboring gene small nucleolar RNA SNORA79 Neighboring gene nucleic acid binding protein 2 Neighboring gene small nucleolar RNA SNORA55 Neighboring gene transfer RNA serine (anticodon CGA) 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels. Zheng J, et al. Int J Mol Med, 2019 Apr. PMID 30720051, Free PMC Article
  2. Transcriptional Effects of E3 Ligase Nrdp1 on Hypertrophy in Neonatal Rat Cardiomyocytes by Microarray and Integrated Gene Network Analysis. Zhang Y, et al. Cardiology, 2016. PMID 27428330
  3. Nrdp1 is Associated with Neuronal Apoptosis in Lipopolysaccharide-Induced Neuroinflammation. Shen J, et al. Neurochem Res, 2015 May. PMID 25896295
  4. Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3. Zhu J, et al. Neurotox Res, 2020 Jun. PMID 32200526
  5. Association between RNF41 gene c.-206 T > A genetic polymorphism and risk of congenital heart diseases in the Chinese Mongolian population. Zhang Y, et al. Genet Mol Res, 2016 Jun 17. PMID 27323192

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3.
    Title: Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3.
  2. Nrdp1 serves an important role in regulating the apoptosis induced by cardiopulmonary bypass in vivo and in vitro through regulating ErbB3 and phosphoAKT protein levels.
    Title: Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels.
  3. Pathway network analysis identified myocardial metabolism, DNA replication, and the cell cycle as the most important pathways targeted by Nrdp1.
    Title: Transcriptional Effects of E3 Ligase Nrdp1 on Hypertrophy in Neonatal Rat Cardiomyocytes by Microarray and Integrated Gene Network Analysis.
  4. The expression of Rnf41 was significantly increased in the cerebral cortex in a neuroinflammation model.
    Title: Nrdp1 is Associated with Neuronal Apoptosis in Lipopolysaccharide-Induced Neuroinflammation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables erythropoietin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-3 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NRDP1
NP_001012195.1
NP_001387996.1
NP_001387997.1
NP_001387998.1
XP_006240838.1
XP_038935300.1
XP_038935301.1
XP_038935303.1
XP_038935304.1
XP_038935305.1
XP_063119773.1
XP_063119774.1
XP_063119775.1
XP_063119776.1
XP_063119777.1
XP_063119778.1
XP_063119779.1
XP_063119780.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012195.1 → NP_001012195.1  E3 ubiquitin-protein ligase NRDP1 isoform 2

    See identical proteins and their annotated locations for NP_001012195.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083614
    UniProtKB/TrEMBL
    A0A0G2K4P8, A0A8J8XH25
    Related
    ENSRNOP00000105032.1, ENSRNOT00000141904.1
    Conserved Domains (2) summary
    pfam08941
    Location:117 → 295
    USP8_interact; USP8 interacting
    cl17238
    Location:15 → 37
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_001401067.1 → NP_001387996.1  E3 ubiquitin-protein ligase NRDP1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6KSD2, G3V930, Q5XIR0

  3. NM_001401068.1 → NP_001387997.1  E3 ubiquitin-protein ligase NRDP1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6KSD2, G3V930, Q5XIR0

  4. NM_001401069.1 → NP_001387998.1  E3 ubiquitin-protein ligase NRDP1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6KSD2, G3V930, Q5XIR0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    1422651..1461700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079375.2 → XP_038935303.1  E3 ubiquitin-protein ligase NRDP1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4P8, A0A8J8XH25
    Conserved Domains (2) summary
    pfam08941
    Location:117 → 295
    USP8_interact; USP8 interacting
    cl17238
    Location:15 → 37
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_063263706.1 → XP_063119776.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

    UniProtKB/TrEMBL
    A6KSD2, G3V930, Q5XIR0

  3. XM_006240776.5 → XP_006240838.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

    See identical proteins and their annotated locations for XP_006240838.1

    UniProtKB/TrEMBL
    A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
    Related
    ENSRNOP00000034376.5, ENSRNOT00000029778.6
    Conserved Domains (2) summary
    cd16634
    Location:15 → 57
    mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
    pfam08941
    Location:137 → 315
    USP8_interact; USP8 interacting

  4. XM_063263705.1 → XP_063119775.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

    UniProtKB/TrEMBL
    A6KSD2, G3V930, Q5XIR0

  5. XM_063263708.1 → XP_063119778.1  E3 ubiquitin-protein ligase NRDP1 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XH25

  6. XM_039079373.2 → XP_038935301.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
    Conserved Domains (2) summary
    cd16634
    Location:15 → 57
    mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
    pfam08941
    Location:137 → 315
    USP8_interact; USP8 interacting

  7. XM_039079372.2 → XP_038935300.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
    Conserved Domains (2) summary
    cd16634
    Location:15 → 57
    mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
    pfam08941
    Location:137 → 315
    USP8_interact; USP8 interacting

  8. XM_063263709.1 → XP_063119779.1  E3 ubiquitin-protein ligase NRDP1 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XH25

  9. XM_063263704.1 → XP_063119774.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

    UniProtKB/TrEMBL
    A6KSD2, G3V930, Q5XIR0

  10. XM_063263710.1 → XP_063119780.1  E3 ubiquitin-protein ligase NRDP1 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XH25

  11. XM_063263707.1 → XP_063119777.1  E3 ubiquitin-protein ligase NRDP1 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XH25

  12. XM_063263703.1 → XP_063119773.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

    UniProtKB/TrEMBL
    A6KSD2, G3V930, Q5XIR0

  13. XM_039079376.2 → XP_038935304.1  E3 ubiquitin-protein ligase NRDP1 isoform X3

    Conserved Domains (1) summary
    pfam08941
    Location:14 → 192
    USP8_interact; USP8 interacting

  14. XM_039079377.2 → XP_038935305.1  E3 ubiquitin-protein ligase NRDP1 isoform X3

    Conserved Domains (1) summary
    pfam08941
    Location:14 → 192
    USP8_interact; USP8 interacting
Nucleotide Protein Strain
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