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Marchf2 membrane associated ring-CH-type finger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362849, updated on 17-Aug-2024

Summary

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Official Symbol
Marchf2provided by RGD
Official Full Name
membrane associated ring-CH-type finger 2provided by RGD
Primary source
RGD:1306395
See related
EnsemblRapid:ENSRNOG00000007769 AllianceGenome:RGD:1306395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
March2; RNF172; MARCH-II; RGD1306395
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasmic vesicle; cytosol; and endoplasmic reticulum. Orthologous to human MARCHF2 (membrane associated ring-CH-type finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 846.5), Heart (RPKM 578.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Marchf2 in Genome Data Viewer
Location:
7q13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (15183931..15209988, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (14480605..14507821, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (18559301..18585351, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093540 Neighboring gene zinc finger protein 414 Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene RAB11B, member RAS oncogene family Neighboring gene ribosomal protein lateral stalk subunit P1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II. Fukuda H, et al. J Biochem, 2006 Jan. PMID 16428329
  2. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. Nakamura N, et al. Mol Biol Cell, 2005 Apr. PMID 15689499, Free PMC Article
  3. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. Bartee E, et al. J Virol, 2004 Feb. PMID 14722266, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibacterial innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in antibacterial innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in antiviral innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of lysosomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of lysosomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in suppression of viral release by host IEA
Inferred from Electronic Annotation
more info
  
involved_in suppression of viral release by host ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF2
Names
E3 ubiquitin-protein ligase MARCH2
RING finger protein 172
RING-type E3 ubiquitin transferase MARCH2
RING-type E3 ubiquitin transferase MARCHF2
membrane associated RING-CH finger protein II
membrane-associated RING finger protein 2
membrane-associated RING-CH protein II
membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
syntaxin-6-binding protein
NP_001029280.1
XP_006241188.1
XP_006241189.1
XP_008763423.1
XP_038935345.1
XP_063119824.1
XP_063119825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034108.1 → NP_001029280.1  E3 ubiquitin-protein ligase MARCHF2

    See identical proteins and their annotated locations for NP_001029280.1

    Status: VALIDATED

    Source sequence(s)
    AI578941, BC088286
    UniProtKB/Swiss-Prot
    Q5I0I2
    UniProtKB/TrEMBL
    A0A8I6AGT0, A6KQH7
    Conserved Domains (2) summary
    pfam00558
    Location:173 → 224
    Vpu; Vpu protein
    cd16808
    Location:62 → 113
    RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    15183931..15209988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765201.4 → XP_008763423.1  E3 ubiquitin-protein ligase MARCHF2 isoform X4

    Conserved Domains (1) summary
    smart00744
    Location:63 → 110
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  2. XM_006241126.4 → XP_006241188.1  E3 ubiquitin-protein ligase MARCHF2 isoform X2

    Related
    ENSRNOP00000010399.6, ENSRNOT00000010399.9
    Conserved Domains (1) summary
    smart00744
    Location:63 → 110
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  3. XM_006241127.5 → XP_006241189.1  E3 ubiquitin-protein ligase MARCHF2 isoform X3

    Conserved Domains (1) summary
    smart00744
    Location:63 → 110
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  4. XM_039079417.2 → XP_038935345.1  E3 ubiquitin-protein ligase MARCHF2 isoform X1

    Conserved Domains (1) summary
    cd16808
    Location:62 → 113
    RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)

  5. XM_063263754.1 → XP_063119824.1  E3 ubiquitin-protein ligase MARCHF2 isoform X5

  6. XM_063263755.1 → XP_063119825.1  E3 ubiquitin-protein ligase MARCHF2 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012196.2: Suppressed sequence

    Description
    NM_001012196.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0I2.1 GenPept UniProtKB/Swiss-Prot:Q5I0I2

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