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Chpt1 choline phosphotransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362866, updated on 10-Jul-2024

Summary

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Official Symbol
Chpt1provided by RGD
Official Full Name
choline phosphotransferase 1provided by RGD
Primary source
RGD:1359283
See related
EnsemblRapid:ENSRNOG00000058271 AllianceGenome:RGD:1359283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable diacylglycerol cholinephosphotransferase activity. Predicted to be involved in platelet activating factor biosynthetic process. Predicted to act upstream of or within phosphatidylcholine biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. Orthologous to human CHPT1 (choline phosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 494.2), Heart (RPKM 384.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chpt1 in Genome Data Viewer
Location:
7q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (24753880..24802529, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (22866455..22915111, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (29019518..29070928, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene proline-rich basic protein 1, pseudogene 1 Neighboring gene DNA-damage regulated autophagy modulator 1 Neighboring gene N-acetylglucosamine-1-phosphate transferase subunits alpha and beta Neighboring gene synaptonemal complex protein 3 Neighboring gene uncharacterized LOC102554140 Neighboring gene myosin binding protein C1 Neighboring gene uncharacterized LOC120093549

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Altered mouse cholinephosphotransferase gene expression in kidneys of type 2 diabetic KK/TA mouse. Gohda T, et al. Metabolism, 2004 Jul. PMID 15254874
  2. Cloning, genomic organization, and characterization of a human cholinephosphotransferase. Henneberry AL, et al. J Biol Chem, 2000 Sep 22. PMID 10893425
  3. Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination. Butler PL, et al. J Biol Chem, 2010 Feb 26. PMID 20018880, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC95241

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables diacylglycerol cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diacylglycerol cholinephosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol cholinephosphotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet activating factor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet activating factor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cholinephosphotransferase 1
Names
cholinephosphotransferase 1 alpha
diacylglycerol cholinephosphotransferase 1
NP_001381255.1
XP_006241292.1
XP_038935364.1
XP_038935367.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394326.1 → NP_001381255.1  cholinephosphotransferase 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q66H21
    Related
    ENSRNOP00000102864.1, ENSRNOT00000167914.1
    Conserved Domains (1) summary
    cl00453
    Location:25 → 337
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RNA

  1. NR_172095.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    24753880..24802529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079436.2 → XP_038935364.1  cholinephosphotransferase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZB6
    Related
    ENSRNOP00000106967.1, ENSRNOT00000162025.1
    Conserved Domains (1) summary
    cl00453
    Location:25 → 337
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  2. XM_006241230.4 → XP_006241292.1  cholinephosphotransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GI18
    Related
    ENSRNOP00000084340.2, ENSRNOT00000094926.2
    Conserved Domains (1) summary
    cl00453
    Location:25 → 337
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  3. XM_039079439.2 → XP_038935367.1  cholinephosphotransferase 1 isoform X3

    Conserved Domains (1) summary
    cl00453
    Location:25 → 207
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H21.1 GenPept UniProtKB/Swiss-Prot:Q66H21

Gene LinkOut

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