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Stac3 SH3 and cysteine rich domain 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362895, updated on 18-Sep-2024

Summary

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Official Symbol
Stac3provided by RGD
Official Full Name
SH3 and cysteine rich domain 3provided by RGD
Primary source
RGD:1308964
See related
EnsemblRapid:ENSRNOG00000008050 AllianceGenome:RGD:1308964
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including neuromuscular synaptic transmission; positive regulation of protein localization to plasma membrane; and positive regulation of voltage-gated calcium channel activity. Predicted to act upstream of or within skeletal muscle fiber development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of voltage-gated calcium channel complex. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC3 (SH3 and cysteine rich domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 601.4) and Liver (RPKM 80.5) See more
Orthologs
human mouse all
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Genomic context

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See Stac3 in Genome Data Viewer
Location:
7q22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (65227151..65235884)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63343078..63350590)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70807427..70815271)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene R3H domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene peptidyl-prolyl cis-trans isomerase D-like Neighboring gene NDUFA4, mitochondrial complex associated like 2 Neighboring gene serine hydroxymethyltransferase 2 Neighboring gene neurexophilin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. STAC3 stably interacts through its C1 domain with Ca(V)1.1 in skeletal muscle triads. Campiglio M, et al. Sci Rep, 2017 Jan 23. PMID 28112192, Free PMC Article
  2. Stac3 is a novel regulator of skeletal muscle development in mice. Reinholt BM, et al. PLoS One, 2013. PMID 23626854, Free PMC Article
  3. Testicular STAC3 regulates Leydig cell steroidogenesis through potentiating mitochondrial membrane potential and StAR processing. Bi X, et al. Cell Tissue Res, 2021 Apr. PMID 33409656, Free PMC Article
  4. Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation. Polster A, et al. Proc Natl Acad Sci U S A, 2016 Sep 27. PMID 27621462, Free PMC Article
  5. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. Polster A, et al. J Gen Physiol, 2018 Apr 2. PMID 29467163, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Testicular STAC3 regulates Leydig cell steroidogenesis through potentiating mitochondrial membrane potential and StAR processing.
    Title: Testicular STAC3 regulates Leydig cell steroidogenesis through potentiating mitochondrial membrane potential and StAR processing.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neuromuscular synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle fiber development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 and cysteine-rich domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130558.1 → NP_001124030.1  SH3 and cysteine-rich domain-containing protein 3

    See identical proteins and their annotated locations for NP_001124030.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A6HQV7, D3ZQN6
    Conserved Domains (4) summary
    cd11834
    Location:307 → 357
    SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
    cd11986
    Location:248 → 300
    SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
    pfam00130
    Location:89 → 134
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam16664
    Location:146 → 218
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    65227151..65235884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263831.1 → XP_063119901.1  SH3 and cysteine-rich domain-containing protein 3 isoform X2

  2. XM_063263829.1 → XP_063119899.1  SH3 and cysteine-rich domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A6HQV7, D3ZQN6

  3. XM_063263830.1 → XP_063119900.1  SH3 and cysteine-rich domain-containing protein 3 isoform X2

  4. XM_017594944.3 → XP_017450433.1  SH3 and cysteine-rich domain-containing protein 3 isoform X2

    Related
    ENSRNOP00000110246.1, ENSRNOT00000148777.1

  5. XM_008765415.4 → XP_008763637.1  SH3 and cysteine-rich domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_008763637.1

    UniProtKB/TrEMBL
    A6HQV7, D3ZQN6
    Conserved Domains (4) summary
    cd11834
    Location:307 → 357
    SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
    cd11986
    Location:248 → 300
    SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
    pfam00130
    Location:89 → 134
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam16664
    Location:146 → 218
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2

  6. XM_006241486.5 → XP_006241548.1  SH3 and cysteine-rich domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006241548.1

    UniProtKB/TrEMBL
    A6HQV7, D3ZQN6
    Related
    ENSRNOP00000010639.4, ENSRNOT00000010639.6
    Conserved Domains (4) summary
    cd11834
    Location:307 → 357
    SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
    cd11986
    Location:248 → 300
    SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
    pfam00130
    Location:89 → 134
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam16664
    Location:146 → 218
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2

  7. XM_006241488.5 → XP_006241550.1  SH3 and cysteine-rich domain-containing protein 3 isoform X3

    Conserved Domains (4) summary
    cd11834
    Location:268 → 318
    SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
    cd11986
    Location:209 → 261
    SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
    pfam00130
    Location:50 → 95
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam16664
    Location:107 → 179
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
Nucleotide Protein Strain
Heading Accession and Version

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