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Sgsm3 small G protein signaling modulator 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362963, updated on 2-Nov-2024

Summary

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Official Symbol
Sgsm3provided by RGD
Official Full Name
small G protein signaling modulator 3provided by RGD
Primary source
RGD:735113
See related
EnsemblRapid:ENSRNOG00000018745 AllianceGenome:RGD:735113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rutbc3; bdif-1
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including Rap protein signal transduction; positive regulation of GTPase activity; and regulation of Rab protein signal transduction. Predicted to be located in cytosol and gap junction. Orthologous to human SGSM3 (small G protein signaling modulator 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 74.2), Muscle (RPKM 54.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sgsm3 in Genome Data Viewer
Location:
7q34
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (114394724..114424285)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (112514453..112544109)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122203498..122232993)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing adaptor 6B Neighboring gene uncharacterized LOC120093695 Neighboring gene SREK1-interacting protein 1, pseudogene 1 Neighboring gene adenylosuccinate lyase Neighboring gene myocardin related transcription factor A Neighboring gene thymosin, beta 10, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction of small G protein signaling modulator 3 with connexin 43 contributes to myocardial infarction in rat hearts. Lee CY, et al. Biochem Biophys Res Commun, 2017 Sep 16. PMID 28716730
  2. The identification of novel protein, brain-derived integrating factor-1 (BDIF1), which interacts with astrocytic gap junctional protein. Ito T, et al. Neurosci Res, 2011 Jul. PMID 21453730
  3. Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Lan Z, et al. Biochemistry, 2005 Feb 22. PMID 15709751, Free PMC Article
  4. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Yang H, et al. Genomics, 2007 Aug. PMID 17509819
  5. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. Fuchs E, et al. J Cell Biol, 2007 Jun 18. PMID 17562788, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High levels of SGSM3 appeared to induce the turnover of Cx43 through lysosomal degradation in myocardial infarcted rat hearts.
    Title: Interaction of small G protein signaling modulator 3 with connexin 43 contributes to myocardial infarction in rat hearts.
  2. BDIF1 potentially functions in molecular trafficking of astrocytes.
    Title: The identification of novel protein, brain-derived integrating factor-1 (BDIF1), which interacts with astrocytic gap junctional protein.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Rap protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in Rap protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in Rap protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasma membrane to endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in plasma membrane to endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rab protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rab protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in gap junction IEA
Inferred from Electronic Annotation
more info
  
located_in gap junction ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small G protein signaling modulator 3
Names
RUN and TBC1 domain containing 3
RUN and TBC1 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198787.2 → NP_942082.2  small G protein signaling modulator 3

    See identical proteins and their annotated locations for NP_942082.2

    Status: VALIDATED

    Source sequence(s)
    BC062060, BM385615, CB581701
    UniProtKB/TrEMBL
    A6HSY2, F1LQU9
    Related
    ENSRNOP00000025381.4, ENSRNOT00000025382.7
    Conserved Domains (3) summary
    cd11813
    Location:497 → 549
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:127 → 338
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:576 → 727
    RUN; RUN domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    114394724..114424285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242099.5 → XP_006242161.1  small G protein signaling modulator 3 isoform X2

    UniProtKB/TrEMBL
    A6HSY2
    Conserved Domains (3) summary
    cd11813
    Location:497 → 549
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:127 → 338
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:576 → 730
    RUN; RUN domain

  2. XM_063263929.1 → XP_063119999.1  small G protein signaling modulator 3 isoform X2

  3. XM_006242096.5 → XP_006242158.1  small G protein signaling modulator 3 isoform X1

    See identical proteins and their annotated locations for XP_006242158.1

    UniProtKB/TrEMBL
    A6HSY2, F1LQU9
    Conserved Domains (3) summary
    cd11813
    Location:497 → 549
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:127 → 338
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:576 → 727
    RUN; RUN domain

  4. XM_063263928.1 → XP_063119998.1  small G protein signaling modulator 3 isoform X1

    UniProtKB/TrEMBL
    F1LQU9

  5. XM_039079595.2 → XP_038935523.1  small G protein signaling modulator 3 isoform X1

    UniProtKB/TrEMBL
    A6HSY2, F1LQU9
    Related
    ENSRNOP00000080335.1, ENSRNOT00000101805.2
    Conserved Domains (3) summary
    cd11813
    Location:497 → 549
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:127 → 338
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:576 → 727
    RUN; RUN domain

  6. XM_063263927.1 → XP_063119997.1  small G protein signaling modulator 3 isoform X1

    UniProtKB/TrEMBL
    F1LQU9

  7. XM_017594989.3 → XP_017450478.1  small G protein signaling modulator 3 isoform X1

    UniProtKB/TrEMBL
    A6HSY2, F1LQU9
    Conserved Domains (3) summary
    cd11813
    Location:497 → 549
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:127 → 338
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:576 → 727
    RUN; RUN domain

  8. XM_063263926.1 → XP_063119996.1  small G protein signaling modulator 3 isoform X1

    UniProtKB/TrEMBL
    F1LQU9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6R7.1 GenPept UniProtKB/Swiss-Prot:Q6P6R7

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