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Ttll1 TTL family tubulin polyglutamylase complex subunit L1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362969, updated on 17-Aug-2024

Summary

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Official Symbol
Ttll1provided by RGD
Official Full Name
TTL family tubulin polyglutamylase complex subunit L1provided by RGD
Primary source
RGD:1309124
See related
EnsemblRapid:ENSRNOG00000010141 AllianceGenome:RGD:1309124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PGs3
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within several processes, including cerebellar Purkinje cell differentiation; mucociliary clearance; and regulation of blastocyst development. Predicted to be located in ciliary basal body. Predicted to be active in cilium. Orthologous to human TTLL1 (tubulin tyrosine ligase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 42.8), Thymus (RPKM 27.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116499536..116528833, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114619509..114648850, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124338396..124367719, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene protein kinase C and casein kinase substrate in neurons 2 Neighboring gene uncharacterized LOC120093699 Neighboring gene BCL2-interacting killer Neighboring gene uncharacterized LOC134479952 Neighboring gene malonyl-CoA-acyl carrier protein transacylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice. Suzuki H, et al. Sci Rep, 2018 Feb 13. PMID 29440671, Free PMC Article
  2. Tubulin tyrosine ligase-like 1 deficiency results in chronic rhinosinusitis and abnormal development of spermatid flagella in mice. Vogel P, et al. Vet Pathol, 2010 Jul. PMID 20442420
  3. Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Ikegami K, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498047, Free PMC Article
  4. Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport. Magiera MM, et al. EMBO J, 2018 Dec 3. PMID 30420556, Free PMC Article
  5. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin-glutamic acid ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune response in nasopharyngeal-associated lymphoid tissue ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mucociliary clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of blastocyst development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sperm axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polyglutamylase complex subunit TTLL1
Names
probable tubulin polyglutamylase TTLL1
tubulin polyglutamylase TTLL1
tubulin polyglutamylase complex subunit 3
tubulin tyrosine ligase like 1
tubulin tyrosine ligase-like family, member 1
tubulin--tyrosine ligase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012200.2 → NP_001012200.1  polyglutamylase complex subunit TTLL1

    See identical proteins and their annotated locations for NP_001012200.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q5PPI9
    UniProtKB/TrEMBL
    A0A8I6G7K0
    Conserved Domains (1) summary
    pfam03133
    Location:59 → 364
    TTL; Tubulin-tyrosine ligase family

  2. NM_001393857.1 → NP_001380786.1  polyglutamylase complex subunit TTLL1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q5PPI9
    UniProtKB/TrEMBL
    A0A8I6G7K0
    Related
    ENSRNOP00000052832.4, ENSRNOT00000055978.6
    Conserved Domains (1) summary
    pfam03133
    Location:59 → 364
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    116499536..116528833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263933.1 → XP_063120003.1  polyglutamylase complex subunit TTLL1 isoform X2

  2. XM_039079601.2 → XP_038935529.1  polyglutamylase complex subunit TTLL1 isoform X4

    Conserved Domains (1) summary
    pfam03133
    Location:7 → 264
    TTL; Tubulin-tyrosine ligase family

  3. XM_063263932.1 → XP_063120002.1  polyglutamylase complex subunit TTLL1 isoform X1

    Related
    ENSRNOP00000081132.2, ENSRNOT00000110361.2

  4. XM_006242104.3 → XP_006242166.1  polyglutamylase complex subunit TTLL1 isoform X3

    See identical proteins and their annotated locations for XP_006242166.1

    UniProtKB/Swiss-Prot
    Q5PPI9
    UniProtKB/TrEMBL
    A0A8I6G7K0
    Conserved Domains (1) summary
    pfam03133
    Location:59 → 364
    TTL; Tubulin-tyrosine ligase family

  5. XM_063263935.1 → XP_063120005.1  polyglutamylase complex subunit TTLL1 isoform X3

    UniProtKB/Swiss-Prot
    Q5PPI9
    UniProtKB/TrEMBL
    A0A8I6G7K0

  6. XM_063263934.1 → XP_063120004.1  polyglutamylase complex subunit TTLL1 isoform X3

    UniProtKB/Swiss-Prot
    Q5PPI9
    UniProtKB/TrEMBL
    A0A8I6G7K0

  7. XM_063263937.1 → XP_063120007.1  polyglutamylase complex subunit TTLL1 isoform X4

RNA

  1. XR_010053012.1 RNA Sequence

  2. XR_010053011.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PPI9.1 GenPept UniProtKB/Swiss-Prot:Q5PPI9

Gene LinkOut

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