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Anln anillin, actin binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 363031, updated on 2-Nov-2024

Summary

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Official Symbol
Anlnprovided by RGD
Official Full Name
anillin, actin binding proteinprovided by RGD
Primary source
RGD:1561367
See related
EnsemblRapid:ENSRNOG00000014343 AllianceGenome:RGD:1561367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561367
Summary
Predicted to enable actin binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; podocyte cell migration; and positive regulation of bleb assembly. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in several cellular components, including bleb; midbody; and nucleoplasm. Predicted to be active in actomyosin contractile ring. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin, actin binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 101.6), Spleen (RPKM 76.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Anln in Genome Data Viewer
Location:
8q13
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (29134222..29197513, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20858227..20921602, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23336455..23397122, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480148 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene zinc finger protein 717 Neighboring gene microtubule associated tyrosine carboxypeptidase 2 Neighboring gene uncharacterized LOC134480149 Neighboring gene RP9, pre-mRNA splicing factor Neighboring gene Bardet-Biedl syndrome 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis. Oegema K, et al. J Cell Biol, 2000 Aug 7. PMID 10931866, Free PMC Article
  2. Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. Gbadegesin RA, et al. J Am Soc Nephrol, 2014 Sep. PMID 24676636, Free PMC Article
  3. Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase. Kiyomitsu T, et al. Cell, 2013 Jul 18. PMID 23870127, Free PMC Article
  4. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actomyosin contractile ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in podocyte cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of bleb assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in septin ring organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actomyosin contractile ring ISO
Inferred from Sequence Orthology
more info
  
located_in bleb ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anillin
Names
actin-binding protein anillin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427480.1 → NP_001414409.1  anillin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AE68
    Related
    ENSRNOP00000092584.1, ENSRNOT00000098083.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    29134222..29197513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082267.2 → XP_038938195.1  anillin isoform X1

    UniProtKB/TrEMBL
    A0A8I6AE50
    Related
    ENSRNOP00000092675.2, ENSRNOT00000109771.2
    Conserved Domains (4) summary
    PHA03307
    Location:26 → 200
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01263
    Location:993 → 1120
    PH_anillin; Anillin Pleckstrin homology (PH) domain
    pfam08174
    Location:792 → 945
    Anillin; Cell division protein anillin
    pfam16018
    Location:135 → 221
    Anillin_N; Anillin N-terminus
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials