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Zw10 zw10 kinetochore protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 363059, updated on 2-Nov-2024

Summary

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Official Symbol
Zw10provided by RGD
Official Full Name
zw10 kinetochore proteinprovided by RGD
Primary source
RGD:1309197
See related
EnsemblRapid:ENSRNOG00000054479 AllianceGenome:RGD:1309197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase chromosome alignment; and regulation of mitotic cell cycle phase transition. Predicted to be located in several cellular components, including kinetochore; lipid droplet; and spindle. Predicted to be part of Dsl1/NZR complex and RZZ complex. Orthologous to human ZW10 (zw10 kinetochore protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 112.1), Muscle (RPKM 84.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zw10 in Genome Data Viewer
Location:
8q23
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (58292959..58317881)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (49396541..49424743)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (53365881..53390742)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 28 Neighboring gene PCNA clamp associated factor, pseudogene 4 Neighboring gene claudin 25 Neighboring gene transmembrane serine protease 5 Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin. Arasaki K, et al. Biochem Biophys Res Commun, 2007 Aug 3. PMID 17560939
  2. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. Wang H, et al. J Biol Chem, 2004 Dec 24. PMID 15485811
  3. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. Chan GK, et al. Nat Cell Biol, 2000 Dec. PMID 11146660
  4. Rab33b and Rab6 are functionally overlapping regulators of Golgi homeostasis and trafficking. Starr T, et al. Traffic, 2010 May. PMID 20163571
  5. Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint. Sivaram MV, et al. EMBO J, 2009 Apr 8. PMID 19229290, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. targeting of ZW10 to the perinuclear Golgi region was found to depend on the perinuclear accumulation of dynactin
    Title: Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of exit from mitosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of exit from mitosis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Dsl1/NZR complex ISO
Inferred from Sequence Orthology
more info
  
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RZZ complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
centromere/kinetochore protein zw10 homolog
Names
ZW10 homolog, centromere/kinetochore protein
ZW10, kinetochore associated, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024801.2 → NP_001019972.1  centromere/kinetochore protein zw10 homolog isoform 1

    See identical proteins and their annotated locations for NP_001019972.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q4V8C2
    UniProtKB/TrEMBL
    A6J4B1
    Related
    ENSRNOP00000071533.1, ENSRNOT00000080712.3
    Conserved Domains (1) summary
    pfam06248
    Location:9 → 561
    Zw10; Centromere/kinetochore Zw10

  2. NM_001429477.1 → NP_001416406.1  centromere/kinetochore protein zw10 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    58292959..58317881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265741.1 → XP_063121811.1  centromere/kinetochore protein zw10 homolog isoform X1

  2. XM_039081724.2 → XP_038937652.2  centromere/kinetochore protein zw10 homolog isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8C2.3 GenPept UniProtKB/Swiss-Prot:Q4V8C2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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