U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Commd4 COMM domain containing 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363068, updated on 10-Jul-2024

Summary

Official Symbol
Commd4provided by RGD
Official Full Name
COMM domain containing 4provided by RGD
Primary source
RGD:1306104
See related
EnsemblRapid:ENSRNOG00000018671 AllianceGenome:RGD:1306104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Orthologous to human COMMD4 (COMM domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 226.5), Kidney (RPKM 187.1) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Commd4 in Genome Data Viewer
Location:
8q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66462188..66465700, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57566236..57569701, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61833340..61836872, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene nei-like DNA glycosylase 1 Neighboring gene voltage-dependent anion channel 2, pseudogene 2 Neighboring gene uncharacterized LOC103693103

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
COMM domain-containing protein 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108762.1NP_001102232.1  COMM domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001102232.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473975
    UniProtKB/TrEMBL
    A0A0G2K6N9, A6J4T1, D4A2Q7
    Related
    ENSRNOP00000061735.1, ENSRNOT00000064903.3
    Conserved Domains (1) summary
    cl06336
    Location:26176
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  2. NM_001401178.1NP_001388107.1  COMM domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K6N9, A6J4T2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    66462188..66465700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265755.1XP_063121825.1  COMM domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6N9