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Dis3l DIS3-like exosome 3'-5' exoribonuclease [ Rattus norvegicus (Norway rat) ]

Gene ID: 363077, updated on 17-Aug-2024

Summary

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Official Symbol
Dis3lprovided by RGD
Official Full Name
DIS3-like exosome 3'-5' exoribonucleaseprovided by RGD
Primary source
RGD:1308959
See related
EnsemblRapid:ENSRNOG00000010537 AllianceGenome:RGD:1308959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308959
Summary
Predicted to enable 3'-5'-exoribonuclease activity and enzyme binding activity. Predicted to be involved in rRNA catabolic process. Predicted to be located in centrosome; cytosol; and plasma membrane. Predicted to be part of cytoplasmic exosome (RNase complex). Orthologous to human DIS3L (DIS3 like exosome 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 131.6), Kidney (RPKM 97.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dis3l in Genome Data Viewer
Location:
8q24
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (73699185..73735581, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (64803925..64840306, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (69771211..69807880, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) 48 Neighboring gene small Cajal body-specific RNA 14 Neighboring gene timeless interacting protein Neighboring gene multiple EGF-like-domains 11 Neighboring gene uncharacterized LOC134480194 Neighboring gene RAB11a, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94911

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables 3'-5'-RNA exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables exoribonuclease II activity ISO
Inferred from Sequence Orthology
more info
  
enables exoribonuclease II activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic exosome (RNase complex) ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DIS3-like exonuclease 1
Names
DIS3 mitotic control homolog-like
NP_001008381.2
XP_006243325.1
XP_008764533.1
XP_017451228.1
XP_063121836.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008380.2 → NP_001008381.2  DIS3-like exonuclease 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5U2P0
    UniProtKB/TrEMBL
    A6J5C1
    Related
    ENSRNOP00000014071.5, ENSRNOT00000014071.8
    Conserved Domains (3) summary
    COG0557
    Location:265 → 899
    VacB; Exoribonuclease R [Transcription]
    cd09862
    Location:11 → 188
    PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    pfam17215
    Location:881 → 958
    Rrp44_S1; S1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    73699185..73735581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243263.5 → XP_006243325.1  DIS3-like exonuclease 1 isoform X1

    See identical proteins and their annotated locations for XP_006243325.1

    UniProtKB/TrEMBL
    A6J5C2
    Conserved Domains (3) summary
    COG0557
    Location:182 → 816
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:382 → 732
    RNB; RNB domain
    cl14812
    Location:2 → 105
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

  2. XM_063265766.1 → XP_063121836.1  DIS3-like exonuclease 1 isoform X3

  3. XM_017595739.1 → XP_017451228.1  DIS3-like exonuclease 1 isoform X4

  4. XM_008766311.3 → XP_008764533.1  DIS3-like exonuclease 1 isoform X2

    Conserved Domains (3) summary
    COG0557
    Location:265 → 893
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:465 → 815
    RNB; RNB domain
    cl14812
    Location:12 → 188
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2P0.2 GenPept UniProtKB/Swiss-Prot:Q5U2P0

Gene LinkOut

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