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Mindy2 MINDY lysine 48 deubiquitinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363089, updated on 10-Oct-2024

Summary

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Official Symbol
Mindy2provided by RGD
Official Full Name
MINDY lysine 48 deubiquitinase 2provided by RGD
Primary source
RGD:1311456
See related
EnsemblRapid:ENSRNOG00000061337 AllianceGenome:RGD:1311456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam63b; RGD1311456
Summary
Predicted to enable cysteine-type peptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in protein K48-linked deubiquitination. Predicted to be located in nucleoplasm. Orthologous to human MINDY2 (MINDY lysine 48 deubiquitinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 185.7), Lung (RPKM 174.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mindy2 in Genome Data Viewer
Location:
8q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (80149127..80210011, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (71268274..71327698, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (77029346..77089208, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene SAFB-like, transcription modulator Neighboring gene uncharacterized LOC102551907 Neighboring gene ADAM metallopeptidase domain 10 Neighboring gene uncharacterized LOC120094202 Neighboring gene lipase C, hepatic type

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes. Abdul Rehman SA, et al. Mol Cell, 2016 Jul 7. PMID 27292798, Free PMC Article
  2. A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains. Kristariyanto YA, et al. EMBO Rep, 2017 Mar. PMID 28082312, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K11-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K6-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MINDY lysine 48 deubiquitinase 2; ubiquitin carboxyl-terminal hydrolase MINDY-2
Names
family with sequence similarity 63, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429419.1 → NP_001416348.1  MINDY lysine 48 deubiquitinase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    D3ZWA1

  2. NM_001429420.1 → NP_001416349.1  MINDY lysine 48 deubiquitinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZZG8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    80149127..80210011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_343420.11 → XP_343421.3  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X1

    Related
    ENSRNOP00000070456.1, ENSRNOT00000078685.3
    Conserved Domains (1) summary
    pfam04424
    Location:255 → 366
    DUF544; Protein of unknown function (DUF544)

  2. XM_017596087.3 → XP_017451576.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X2

    Related
    ENSRNOP00000083544.1, ENSRNOT00000094906.2

  3. XM_039082503.2 → XP_038938431.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X3

    UniProtKB/TrEMBL
    A6KES6
    Conserved Domains (1) summary
    pfam04424
    Location:255 → 366
    MINDY_DUB; MINDY deubiquitinase
Nucleotide Protein Strain
Heading Accession and Version

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