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Mrap2 melanocortin 2 receptor accessory protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363112, updated on 2-Nov-2024

Summary

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Official Symbol
Mrap2provided by RGD
Official Full Name
melanocortin 2 receptor accessory protein 2provided by RGD
Primary source
RGD:1309873
See related
EnsemblRapid:ENSRNOG00000010545 AllianceGenome:RGD:1309873
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309873
Summary
Predicted to enable identical protein binding activity; melanocortin receptor binding activity; and signaling receptor regulator activity. Predicted to be involved in several processes, including energy reserve metabolic process; negative regulation of protein localization to plasma membrane; and regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be active in endoplasmic reticulum and plasma membrane. Orthologous to human MRAP2 (melanocortin 2 receptor accessory protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 48.3), Thymus (RPKM 26.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrap2 in Genome Data Viewer
Location:
8q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (96968239..97024581)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (88088293..88144636)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (94801336..94858192)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ripply transcriptional repressor 2 Neighboring gene cytochrome b5 reductase 4 Neighboring gene centrosomal protein 162 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. Sebag JA, et al. Sci Signal, 2010 Apr 6. PMID 20371771, Free PMC Article
  2. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Asai M, et al. Science, 2013 Jul 19. PMID 23869016, Free PMC Article
  3. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Chan LF, et al. Proc Natl Acad Sci U S A, 2009 Apr 14. PMID 19329486, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables corticotropin hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables corticotropin hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables type 1 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 1 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables type 3 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 3 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables type 4 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 4 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables type 5 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 5 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in energy reserve metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in feeding behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
melanocortin-2 receptor accessory protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108774.1 → NP_001102244.1  melanocortin-2 receptor accessory protein 2

    See identical proteins and their annotated locations for NP_001102244.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/TrEMBL
    A0A0G2K8R5, A6I1X3, D4AE95
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    96968239..97024581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243488.5 → XP_006243550.1  melanocortin-2 receptor accessory protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006243550.1

    UniProtKB/TrEMBL
    A0A0G2K8R5, A6I1X3, D4AE95
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  2. XM_063265792.1 → XP_063121862.1  melanocortin-2 receptor accessory protein 2 isoform X1

    UniProtKB/TrEMBL
    A6I1X3, D4AE95

  3. XM_006243487.5 → XP_006243549.1  melanocortin-2 receptor accessory protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006243549.1

    UniProtKB/TrEMBL
    A0A0G2K8R5, A6I1X3, D4AE95
    Related
    ENSRNOP00000014006.6, ENSRNOT00000014007.9
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  4. XM_017595743.3 → XP_017451232.1  melanocortin-2 receptor accessory protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8R5, A6I1X3, D4AE95
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  5. XM_063265794.1 → XP_063121864.1  melanocortin-2 receptor accessory protein 2 isoform X1

    UniProtKB/TrEMBL
    A6I1X3, D4AE95

  6. XM_039081764.2 → XP_038937692.1  melanocortin-2 receptor accessory protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8R5, A6I1X3, D4AE95
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  7. XM_039081765.2 → XP_038937693.1  melanocortin-2 receptor accessory protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15183
    Location:1 → 40
    MRAP; Melanocortin-2 receptor accessory protein family
Nucleotide Protein Strain
Heading Accession and Version

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