Slc9a9 solute carrier family 9 member A9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc9a9provided by RGD
Official Full Name: solute carrier family 9 member A9provided by RGD
Primary source: RGD:1560736
See related: EnsemblRapid:ENSRNOG00000008554 AllianceGenome:RGD:1560736
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NHE-9; RGD1560736
Summary: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in endosome membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane and recycling endosome. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SLC9A9 (solute carrier family 9 member A9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 354.4), Spleen (RPKM 86.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (104112279..104675944)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (95232889..95797262)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (102304095..103022619)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

abnormalities in SLC9A9-mediated signaling pathways could contribute to the ADHD phenotype of two rat models
Title: Differential expression of SLC9A9 and interacting molecules in the hippocampus of rat models for attention deficit/hyperactivity disorder.
The SLC9A9 gene sequence and expression profile in prefrontal cortex, dorsal striatum and hippocampus in two genetic rat models of attention deficit hyperactivity disorder, were examined.
Title: SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder.

Submit: New GeneRIF Correction

General gene information

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Markers

D8Got151 (e-PCR)
- UniSTS:112943

AU049605 (e-PCR)
- UniSTS:146051

BF404144 (e-PCR)
- UniSTS:246927

BE116447 (e-PCR)
- UniSTS:248485

D8Got152 (e-PCR)
- UniSTS:115624

RH139530 (e-PCR)
- UniSTS:221616

AU049172 (e-PCR)
- UniSTS:145620

RH140366 (e-PCR)
- UniSTS:222442

D8Got149 (e-PCR)
- UniSTS:111870

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables potassium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in phagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early phagosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/hydrogen exchanger 9

Names: Na(+)/H(+) exchanger 9; solute carrier family 9 (sodium/hydrogen exchanger); solute carrier family 9 member 9; solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271438.2 → NP_001258367.1 sodium/hydrogen exchanger 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

D4A7H1

UniProtKB/TrEMBL

A6I251

Related

ENSRNOP00000011358.7, ENSRNOT00000011358.9

Conserved Domains (1) summary

pfam00999
Location:128 → 486

Na_H_Exchanger; Sodium/hydrogen exchanger family