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Pcbp4 poly(rC) binding protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363133, updated on 10-Jul-2024

Summary

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Official Symbol
Pcbp4provided by RGD
Official Full Name
poly(rC) binding protein 4provided by RGD
Primary source
RGD:1307910
See related
EnsemblRapid:ENSRNOG00000012406 AllianceGenome:RGD:1307910
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in negative regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and regulation of mRNA stability. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human PCBP4 (poly(rC) binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 194.0), Kidney (RPKM 120.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pcbp4 in Genome Data Viewer
Location:
8q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115971751..115981987)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107092688..107103276)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115154848..115165706)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 14A Neighboring gene uncharacterized LOC134480228 Neighboring gene abhydrolase domain containing 14b Neighboring gene G protein-coupled receptor 62 Neighboring gene poly (ADP-ribose) polymerase family, member 3 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene IQ motif containing F1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability. Scoumanne A, et al. Nucleic Acids Res, 2011 Jan. PMID 20817677, Free PMC Article
  2. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Bogdan AR, et al. Trends Biochem Sci, 2016 Mar. PMID 26725301, Free PMC Article
  3. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, et al. Biochim Biophys Acta, 2015 May. PMID 25661197
  4. A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Zheng S, et al. Genome Res, 2013 Jun. PMID 23636947, Free PMC Article
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
poly(rC)-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191883.1 → NP_001178812.1  poly(rC)-binding protein 4

    See identical proteins and their annotated locations for NP_001178812.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZYH1, D3ZCS3
    Related
    ENSRNOP00000084106.2, ENSRNOT00000103224.2
    Conserved Domains (3) summary
    cd22517
    Location:17 → 86
    KH-I_PCBP4_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 4 (PCBP4) and similar proteins
    cd22520
    Location:101 → 172
    KH-I_PCBP4_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 4 (PCBP4) and similar proteins
    cd22523
    Location:241 → 308
    KH-I_PCBP4_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 4 (PCBP4) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    115971751..115981987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265818.1 → XP_063121888.1  poly(rC)-binding protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A961

  2. XM_006243803.5 → XP_006243865.1  poly(rC)-binding protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A961
    Conserved Domains (1) summary
    cl00098
    Location:101 → 172
    KH-I; K homology (KH) RNA-binding domain, type I
Nucleotide Protein Strain
Heading Accession and Version

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