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Stac SH3 and cysteine rich domain [ Rattus norvegicus (Norway rat) ]

Gene ID: 363152, updated on 18-Sep-2024

Summary

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Official Symbol
Stacprovided by RGD
Official Full Name
SH3 and cysteine rich domainprovided by RGD
Primary source
RGD:1305745
See related
EnsemblRapid:ENSRNOG00000008865 AllianceGenome:RGD:1305745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated calcium channel activity; and skeletal muscle contraction. Predicted to act upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated calcium channel activity. Predicted to be located in T-tubule. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human STAC (SH3 and cysteine rich domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 18.0), Adrenal (RPKM 10.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stac in Genome Data Viewer
Location:
8q32
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (120409165..120531394, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (111530800..111653228, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119820664..119941867, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351782 Neighboring gene doublecortin-like kinase 3 Neighboring gene uncharacterized LOC134480100 Neighboring gene transfer RNA proline (anticodon AGG) 10 Neighboring gene uncharacterized LOC120094270 Neighboring gene cAMP regulated phosphoprotein 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A Ca(v)3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane. Rzhepetskyy Y, et al. Channels (Austin), 2016 Sep 2. PMID 27149520, Free PMC Article
  2. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. Polster A, et al. J Gen Physiol, 2018 Apr 2. PMID 29467163, Free PMC Article
  3. Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility. Nelson BR, et al. Proc Natl Acad Sci U S A, 2013 Jul 16. PMID 23818578, Free PMC Article
  4. Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch. Desrochers G, et al. J Biol Chem, 2017 Apr 14. PMID 28235806, Free PMC Article
  5. Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. Fujimoto M, et al. J Biol Chem, 2008 Oct 31. PMID 18755693, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 and cysteine-rich domain-containing protein
Names
src homology three (SH3) and cysteine rich domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108784.1 → NP_001102254.1  SH3 and cysteine-rich domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I3J5, F1M107
    Related
    ENSRNOP00000011780.8, ENSRNOT00000011780.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    120409165..120531394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596138.3 → XP_017451627.1  SH3 and cysteine-rich domain-containing protein isoform X1

  2. XM_017596139.3 → XP_017451628.1  SH3 and cysteine-rich domain-containing protein isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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