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Arpp21 cAMP regulated phosphoprotein 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363153, updated on 2-Nov-2024

Summary

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Official Symbol
Arpp21provided by RGD
Official Full Name
cAMP regulated phosphoprotein 21provided by RGD
Primary source
RGD:1593239
See related
EnsemblRapid:ENSRNOG00000008919 AllianceGenome:RGD:1593239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208; RGD1307215
Summary
Predicted to enable nucleic acid binding activity. Predicted to act upstream of or within cellular response to heat. Predicted to be active in cytoplasm. Orthologous to human ARPP21 (cAMP regulated phosphoprotein 21). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 215.3), Brain (RPKM 172.2) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arpp21 in Genome Data Viewer
Location:
8q32
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (120912964..121077586, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (112034636..112199273, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (120323895..120492790, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480100 Neighboring gene SH3 and cysteine rich domain Neighboring gene transfer RNA proline (anticodon AGG) 10 Neighboring gene uncharacterized LOC120094270 Neighboring gene uncharacterized LOC120094269 Neighboring gene microRNA 128-2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro. Hemmings HC Jr, et al. J Biol Chem, 1989 May 5. PMID 2540203
  2. Characterization of rat ARPP-21 mRNA: sequence analysis, tissue distribution, and regulation. Ehrlich ME, et al. J Neurochem, 1991 Dec. PMID 1940913
  3. Activation of sodium transport in rat erythrocytes by inhibition of protein phosphatases 1 and 2A. Ivanova TI, et al. Comp Biochem Physiol B Biochem Mol Biol, 2006 Sep. PMID 16875859
  4. The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts. Rehfeld F, et al. Nat Commun, 2018 Mar 26. PMID 29581509, Free PMC Article
  5. Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. Bailey MJ, et al. J Biol Chem, 2009 Mar 20. PMID 19103603, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of ARPP21 in the pineal gland increases at night more than 1000%. This probably reflects circadian neural stimulation by the suprachiasmatic nucleus.
    Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
  2. Inhibition of protein phosphatase 1 by protein phosphatase inhibitors activates sodiun transport in rat erytrocytes
    Title: Activation of sodium transport in rat erythrocytes by inhibition of protein phosphatases 1 and 2A.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109368

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cAMP-regulated phosphoprotein 21
Names
cAMP-regulated phosphoprotein (21 kDa)
cyclic AMP-regulated phosphoprotein, 21
protein phosphatase 1, regulatory (inhibitory subunit 1C)
protein phosphatase 1, regulatory subunit 1C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135045.1 → NP_001128517.1  cAMP-regulated phosphoprotein 21 isoform 2

    See identical proteins and their annotated locations for NP_001128517.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    D3ZQR3
    Related
    ENSRNOP00000039268.2, ENSRNOT00000042854.6
    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam11235
    Location:597 → 769
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam12752
    Location:244 → 298
    SUZ; SUZ domain

  2. NM_001135046.1 → NP_001128518.1  cAMP-regulated phosphoprotein 21 isoform 1

    See identical proteins and their annotated locations for NP_001128518.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I3K4, A6I3K8, Q5FVI0
    Related
    ENSRNOP00000033306.3, ENSRNOT00000037199.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    120912964..121077586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243975.5 → XP_006244037.1  cAMP-regulated phosphoprotein 21 isoform X1

    See identical proteins and their annotated locations for XP_006244037.1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  2. XM_039081801.2 → XP_038937729.1  cAMP-regulated phosphoprotein 21 isoform X1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  3. XM_006243974.5 → XP_006244036.1  cAMP-regulated phosphoprotein 21 isoform X1

    See identical proteins and their annotated locations for XP_006244036.1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  4. XM_063265840.1 → XP_063121910.1  cAMP-regulated phosphoprotein 21 isoform X8

  5. XM_017595751.3 → XP_017451240.1  cAMP-regulated phosphoprotein 21 isoform X1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  6. XM_006243980.5 → XP_006244042.1  cAMP-regulated phosphoprotein 21 isoform X1

    See identical proteins and their annotated locations for XP_006244042.1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  7. XM_063265841.1 → XP_063121911.1  cAMP-regulated phosphoprotein 21 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZX87

  8. XM_017595750.3 → XP_017451239.1  cAMP-regulated phosphoprotein 21 isoform X1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  9. XM_039081802.2 → XP_038937730.1  cAMP-regulated phosphoprotein 21 isoform X1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  10. XM_063265839.1 → XP_063121909.1  cAMP-regulated phosphoprotein 21 isoform X1

  11. XM_006243977.5 → XP_006244039.1  cAMP-regulated phosphoprotein 21 isoform X1

    See identical proteins and their annotated locations for XP_006244039.1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  12. XM_039081805.1 → XP_038937733.1  cAMP-regulated phosphoprotein 21 isoform X12

    Conserved Domains (2) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PRK10263
    Location:492 → 714
    PRK10263; DNA translocase FtsK; Provisional

  13. XM_017595760.2 → XP_017451249.1  cAMP-regulated phosphoprotein 21 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZX87

  14. XM_017595758.2 → XP_017451247.1  cAMP-regulated phosphoprotein 21 isoform X8

  15. XM_039081804.1 → XP_038937732.1  cAMP-regulated phosphoprotein 21 isoform X11

    Conserved Domains (2) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PRK10263
    Location:512 → 734
    PRK10263; DNA translocase FtsK; Provisional

  16. XM_017595756.2 → XP_017451245.1  cAMP-regulated phosphoprotein 21 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A885
    Related
    ENSRNOP00000087306.1, ENSRNOT00000100209.2
    Conserved Domains (1) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...

  17. XM_039081803.1 → XP_038937731.1  cAMP-regulated phosphoprotein 21 isoform X6

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:532 → 769
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 298
    SUZ; SUZ domain

  18. XM_017595754.2 → XP_017451243.1  cAMP-regulated phosphoprotein 21 isoform X4

  19. XM_017595752.2 → XP_017451241.1  cAMP-regulated phosphoprotein 21 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JVX9
    Conserved Domains (2) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam12752
    Location:244 → 298
    SUZ; SUZ domain

  20. XM_017595755.2 → XP_017451244.1  cAMP-regulated phosphoprotein 21 isoform X5

    Related
    ENSRNOP00000083589.2, ENSRNOT00000100319.2
    Conserved Domains (2) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  21. XM_017595753.2 → XP_017451242.1  cAMP-regulated phosphoprotein 21 isoform X3

    Conserved Domains (2) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  22. XM_017595757.2 → XP_017451246.1  cAMP-regulated phosphoprotein 21 isoform X9

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam11235
    Location:598 → 770
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  23. XM_006243972.4 → XP_006244034.1  cAMP-regulated phosphoprotein 21 isoform X1

    See identical proteins and their annotated locations for XP_006244034.1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  24. XM_006243976.5 → XP_006244038.1  cAMP-regulated phosphoprotein 21 isoform X1

    See identical proteins and their annotated locations for XP_006244038.1

    Related
    ENSRNOP00000069661.2, ENSRNOT00000085161.3
    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  25. XM_006243973.5 → XP_006244035.1  cAMP-regulated phosphoprotein 21 isoform X1

    See identical proteins and their annotated locations for XP_006244035.1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  26. XM_006243982.5 → XP_006244044.1  cAMP-regulated phosphoprotein 21 isoform X1

    See identical proteins and their annotated locations for XP_006244044.1

    Conserved Domains (3) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:553 → 790
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:244 → 299
    SUZ; SUZ domain

  27. XM_039081806.1 → XP_038937734.1  cAMP-regulated phosphoprotein 21 isoform X13

    UniProtKB/TrEMBL
    A6I3J9
    Conserved Domains (2) summary
    PRK14971
    Location:334 → 457
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam12752
    Location:5 → 35
    SUZ; SUZ domain

  28. XM_017595766.3 → XP_017451255.1  cAMP-regulated phosphoprotein 21 isoform X14

    UniProtKB/TrEMBL
    A0A8I5ZKF3
    Conserved Domains (1) summary
    cd02642
    Location:162 → 223
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...

  29. XM_063265843.1 → XP_063121913.1  cAMP-regulated phosphoprotein 21 isoform X15

    UniProtKB/TrEMBL
    A6I3K4, A6I3K8, Q5FVI0

  30. XM_063265844.1 → XP_063121914.1  cAMP-regulated phosphoprotein 21 isoform X15

    UniProtKB/TrEMBL
    A6I3K4, A6I3K8, Q5FVI0

  31. XM_017595769.3 → XP_017451258.1  cAMP-regulated phosphoprotein 21 isoform X15

    UniProtKB/TrEMBL
    A6I3K4, A6I3K8, Q5FVI0

  32. XM_039081807.2 → XP_038937735.1  cAMP-regulated phosphoprotein 21 isoform X15

    UniProtKB/TrEMBL
    A6I3K4, A6I3K8, Q5FVI0

  33. XM_063265842.1 → XP_063121912.1  cAMP-regulated phosphoprotein 21 isoform X15

    UniProtKB/TrEMBL
    A6I3K4, A6I3K8, Q5FVI0
Nucleotide Protein Strain
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