Gpd1l glycerol-3-phosphate dehydrogenase 1 like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpd1lprovided by RGD
Official Full Name: glycerol-3-phosphate dehydrogenase 1 likeprovided by RGD
Primary source: RGD:1560123
See related: Ensembl:ENSRNOG00000026455 AllianceGenome:RGD:1560123
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpd1l1; RGD1560123
Summary: Predicted to enable sodium channel regulator activity and transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of protein kinase C signaling; positive regulation of protein localization to cell surface; and regulation of sodium ion transport. Predicted to act upstream of or within NADH metabolic process. Predicted to be located in plasma membrane. Predicted to be part of glycerol-3-phosphate dehydrogenase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 205.7), Kidney (RPKM 109.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (123469282..123498948, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (114591103..114620771, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (122957570..122987236, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations of GPD1-L may downregulate Na(v)1.5 by altering the oxidized to reduced NAD(H) balance.
Title: Cardiac Na+ current regulation by pyridine nucleotides.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
NOT enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NAD metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within NADH metabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in NADH oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of glycerol-3-phosphate dehydrogenase (FAD) complex	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycerol-3-phosphate dehydrogenase 1-like protein

Names: glycerol-3-phosphate dehydrogenase 1 like 1

NP_001178814.1

EC 1.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191885.1 → NP_001178814.1 glycerol-3-phosphate dehydrogenase 1-like protein

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

D3ZAP9

Related

ENSRNOP00000036106.4, ENSRNOT00000033976.7

Conserved Domains (3) summary

TIGR03376
Location:7 → 344

glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))

pfam01210
Location:7 → 171

NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus

pfam07479
Location:198 → 337

NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus