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Gpd1l glycerol-3-phosphate dehydrogenase 1 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 363159, updated on 2-May-2024

Summary

Official Symbol
Gpd1lprovided by RGD
Official Full Name
glycerol-3-phosphate dehydrogenase 1 likeprovided by RGD
Primary source
RGD:1560123
See related
Ensembl:ENSRNOG00000026455 AllianceGenome:RGD:1560123
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpd1l1; RGD1560123
Summary
Predicted to enable sodium channel regulator activity and transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of protein kinase C signaling; positive regulation of protein localization to cell surface; and regulation of sodium ion transport. Predicted to act upstream of or within NADH metabolic process. Predicted to be located in plasma membrane. Predicted to be part of glycerol-3-phosphate dehydrogenase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 205.7), Kidney (RPKM 109.6) and 9 other tissues See more
Orthologs
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Genomic context

See Gpd1l in Genome Data Viewer
Location:
8q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (123469282..123498948, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (114591103..114620771, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (122957570..122987236, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene CKLF-like MARVEL transmembrane domain containing 7 Neighboring gene uncharacterized LOC134480243 Neighboring gene CKLF-like MARVEL transmembrane domain containing 8 Neighboring gene U6 spliceosomal RNA Neighboring gene oxysterol binding protein-like 10 Neighboring gene uncharacterized LOC108351789 Neighboring gene uncharacterized LOC120094279

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
NOT enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of glycerol-3-phosphate dehydrogenase (FAD) complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glycerol-3-phosphate dehydrogenase 1-like protein
Names
glycerol-3-phosphate dehydrogenase 1 like 1
NP_001178814.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191885.1NP_001178814.1  glycerol-3-phosphate dehydrogenase 1-like protein

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    D3ZAP9
    Related
    ENSRNOP00000036106.4, ENSRNOT00000033976.7
    Conserved Domains (3) summary
    TIGR03376
    Location:7344
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    pfam01210
    Location:7171
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
    pfam07479
    Location:198337
    NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    123469282..123498948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)