U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Wdr48 WD repeat domain 48 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363164, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Wdr48provided by RGD
Official Full Name
WD repeat domain 48provided by RGD
Primary source
RGD:1309702
See related
EnsemblRapid:ENSRNOG00000016942 AllianceGenome:RGD:1309702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309702
Summary
Predicted to enable double-stranded DNA binding activity; single-stranded DNA binding activity; and ubiquitin binding activity. Predicted to be involved in double-strand break repair via homologous recombination; positive regulation of nitrogen compound metabolic process; and protein deubiquitination. Predicted to act upstream of or within several processes, including animal organ development; positive regulation of epithelial cell proliferation; and regulation of protein monoubiquitination. Predicted to be located in nucleus. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 329.1), Lung (RPKM 137.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Wdr48 in Genome Data Viewer
Location:
8q32
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128499721..128532930)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119622053..119655264)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128577080..128610287)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 11 Neighboring gene prohibitin 1, pseudogene 2 Neighboring gene atherin-like Neighboring gene golgi reassembly stacking protein 1 Neighboring gene tetratricopeptide repeat domain 21A Neighboring gene cysteine and serine rich nuclear protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response. Liang F, et al. Nat Commun, 2019 Jun 28. PMID 31253762, Free PMC Article
  2. Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice. Park E, et al. Mol Cell Biol, 2013 Nov. PMID 24001775, Free PMC Article
  3. UAF1 is a subunit of multiple deubiquitinating enzyme complexes. Cohn MA, et al. J Biol Chem, 2009 Feb 20. PMID 19075014, Free PMC Article
  4. A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Cohn MA, et al. Mol Cell, 2007 Dec 14. PMID 18082604
  5. WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). Gangula NR, et al. J Biol Chem, 2013 Nov 29. PMID 24145035, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic organ development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within seminiferous tubule development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within single fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skin development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
WD repeat-containing protein 48

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135895.2 → NP_001129367.1  WD repeat-containing protein 48

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I3Y0
    Related
    ENSRNOP00000075552.2, ENSRNOT00000082356.3
    Conserved Domains (3) summary
    cd00200
    Location:30 → 286
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:35 → 73
    7WD40; WD40 repeat [structural motif]
    pfam11816
    Location:509 → 672
    DUF3337; Domain of unknown function (DUF3337)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    128499721..128532930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595770.2 → XP_017451259.1  WD repeat-containing protein 48 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KAW5, D3Z8C7
    Related
    ENSRNOP00000088537.2, ENSRNOT00000114700.2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools