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Tcaim T cell activation inhibitor, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 363169, updated on 2-Nov-2024

Summary

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Official Symbol
Tcaimprovided by RGD
Official Full Name
T cell activation inhibitor, mitochondrialprovided by RGD
Primary source
RGD:1560717
See related
EnsemblRapid:ENSRNOG00000004085 AllianceGenome:RGD:1560717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Toag1; TOAG-1; RGD1560717
Summary
Predicted to be active in mitochondrion. Orthologous to human TCAIM (T cell activation inhibitor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 371.6), Muscle (RPKM 170.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tcaim in Genome Data Viewer
Location:
8q32
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (131292275..131323557)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (122414827..122446105)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (131845673..131876896)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690480 Neighboring gene uncharacterized LOC102550701 Neighboring gene microRNA 138-1 Neighboring gene testis and ovary specific TOPAZ 1 Neighboring gene similar to human chromosome 3 open reading frame 86 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger protein 445

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of tolerance associated gene-1, a mitochondrial protein inhibiting T cell activation, can be used to predict response to immune modulating therapies. Keeren K, et al. J Immunol, 2009 Sep 15. PMID 19684086
  2. Identification of gene markers for the prediction of allograft rejection or permanent acceptance. Sawitzki B, et al. Am J Transplant, 2007 May. PMID 17456197
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
T-cell activation inhibitor, mitochondrial
Names
Tolerance-associated gene-1
tolerance-associated gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110838.2 → NP_001104308.2  T-cell activation inhibitor, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    Related
    ENSRNOP00000099894.1, ENSRNOT00000171499.1

  2. NM_001433878.1 → NP_001420807.1  T-cell activation inhibitor, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  3. NM_001433879.1 → NP_001420808.1  T-cell activation inhibitor, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  4. NM_001433880.1 → NP_001420809.1  T-cell activation inhibitor, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  5. NM_001433881.1 → NP_001420810.1  T-cell activation inhibitor, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  6. NM_001433882.1 → NP_001420811.1  T-cell activation inhibitor, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  7. NM_001433883.1 → NP_001420812.1  T-cell activation inhibitor, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  8. NM_001433884.1 → NP_001420813.1  T-cell activation inhibitor, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  9. NM_001433885.1 → NP_001420814.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  10. NM_001433886.1 → NP_001420815.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  11. NM_001433887.1 → NP_001420816.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  12. NM_001433888.1 → NP_001420817.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  13. NM_001433889.1 → NP_001420818.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  14. NM_001433890.1 → NP_001420819.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  15. NM_001433891.1 → NP_001420820.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  16. NM_001433892.1 → NP_001420821.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  17. NM_001433893.1 → NP_001420822.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  18. NM_001433894.1 → NP_001420823.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  19. NM_001433895.1 → NP_001420824.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  20. NM_001433896.1 → NP_001420825.1  T-cell activation inhibitor, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    131292275..131323557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766723.4 → XP_008764945.1  T-cell activation inhibitor, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8I6AN19
    Conserved Domains (2) summary
    pfam14687
    Location:9 → 95
    DUF4460; Domain of unknown function (DUF4460)
    pfam14688
    Location:156 → 456
    DUF4461; Domain of unknown function (DUF4461)

  2. XM_063265855.1 → XP_063121925.1  T-cell activation inhibitor, mitochondrial isoform X5

  3. XM_008766719.4 → XP_008764941.1  T-cell activation inhibitor, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_008764941.1

    UniProtKB/TrEMBL
    A0A8I6AN19
    Conserved Domains (2) summary
    pfam14687
    Location:9 → 95
    DUF4460; Domain of unknown function (DUF4460)
    pfam14688
    Location:156 → 456
    DUF4461; Domain of unknown function (DUF4461)

  4. XM_063265856.1 → XP_063121926.1  T-cell activation inhibitor, mitochondrial isoform X6

  5. XM_008766718.4 → XP_008764940.1  T-cell activation inhibitor, mitochondrial isoform X2

    Related
    ENSRNOP00000094919.2, ENSRNOT00000117252.2
    Conserved Domains (2) summary
    pfam14687
    Location:29 → 115
    DUF4460; Domain of unknown function (DUF4460)
    pfam14688
    Location:176 → 476
    DUF4461; Domain of unknown function (DUF4461)

  6. XM_039081818.2 → XP_038937746.1  T-cell activation inhibitor, mitochondrial isoform X4

    Conserved Domains (2) summary
    pfam14687
    Location:8 → 81
    DUF4460; Domain of unknown function (DUF4460)
    pfam14688
    Location:143 → 443
    DUF4461; Domain of unknown function (DUF4461)

  7. XM_008766720.2 → XP_008764942.1  T-cell activation inhibitor, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_008764942.1

    UniProtKB/TrEMBL
    A0A8I6AN19
    Conserved Domains (2) summary
    pfam14687
    Location:9 → 95
    DUF4460; Domain of unknown function (DUF4460)
    pfam14688
    Location:156 → 456
    DUF4461; Domain of unknown function (DUF4461)

  8. XM_039081817.2 → XP_038937745.1  T-cell activation inhibitor, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q1X7
    Conserved Domains (2) summary
    pfam14687
    Location:33 → 138
    DUF4460; Domain of unknown function (DUF4460)
    pfam14688
    Location:200 → 500
    DUF4461; Domain of unknown function (DUF4461)

  9. XM_006244194.4 → XP_006244256.1  T-cell activation inhibitor, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q1X7
    Conserved Domains (2) summary
    pfam14687
    Location:33 → 138
    DUF4460; Domain of unknown function (DUF4460)
    pfam14688
    Location:200 → 500
    DUF4461; Domain of unknown function (DUF4461)

  10. XM_008766721.3 → XP_008764943.1  T-cell activation inhibitor, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_008764943.1

    UniProtKB/TrEMBL
    A0A8I6AN19
    Conserved Domains (2) summary
    pfam14687
    Location:9 → 95
    DUF4460; Domain of unknown function (DUF4460)
    pfam14688
    Location:156 → 456
    DUF4461; Domain of unknown function (DUF4461)

  11. XM_017595773.3 → XP_017451262.1  T-cell activation inhibitor, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8I6AN19
    Conserved Domains (2) summary
    pfam14687
    Location:9 → 95
    DUF4460; Domain of unknown function (DUF4460)
    pfam14688
    Location:156 → 456
    DUF4461; Domain of unknown function (DUF4461)

  12. XM_063265854.1 → XP_063121924.1  T-cell activation inhibitor, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q1X7
    Related
    ENSRNOP00000005440.6, ENSRNOT00000005440.8

  13. XM_039081821.2 → XP_038937749.1  T-cell activation inhibitor, mitochondrial isoform X5

    Conserved Domains (1) summary
    pfam14688
    Location:34 → 334
    DUF4461; Domain of unknown function (DUF4461)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DKR2.1 GenPept UniProtKB/Swiss-Prot:P0DKR2

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