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Ubr2 ubiquitin protein ligase E3 component n-recognin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363188, updated on 10-Oct-2024

Summary

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Official Symbol
Ubr2provided by RGD
Official Full Name
ubiquitin protein ligase E3 component n-recognin 2provided by RGD
Primary source
RGD:1593237
See related
EnsemblRapid:ENSRNOG00000015813 AllianceGenome:RGD:1593237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable leucine binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; cellular response to leucine; and meiotic nuclear division. Predicted to act upstream of or within male meiosis I; spermatogenesis; and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Predicted to colocalize with chromatin. Orthologous to human UBR2 (ubiquitin protein ligase E3 component n-recognin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 321.8), Heart (RPKM 311.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ubr2 in Genome Data Viewer
Location:
9q12
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21480058..21559936)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (13982427..14062315)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16003058..16080152)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene transcriptional regulating factor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene peripherin 2 Neighboring gene tubulin folding cofactor C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes. Crichton JH, et al. PLoS Genet, 2017 Jul. PMID 28708824, Free PMC Article
  2. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Kume K, et al. Genes Cells, 2010 Apr 1. PMID 20298436
  3. Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells. MacLennan M, et al. Elife, 2017 Aug 14. PMID 28806172, Free PMC Article
  4. Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway. Kwon YT, et al. Mol Cell Biol, 2001 Dec. PMID 11689692, Free PMC Article
  5. Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Kwon YT, et al. Mol Cell Biol, 2003 Nov. PMID 14585983, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-leucine binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2A ubiquitin ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to L-leucine ISO
Inferred from Sequence Orthology
more info
  
involved_in heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in retrotransposon silencing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase UBR2
NP_001171542.2
NP_001399747.1
XP_038939744.1
XP_038939748.1
XP_063123425.1
XP_063123426.1
XP_063123427.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178071.2 → NP_001171542.2  E3 ubiquitin-protein ligase UBR2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    Related
    ENSRNOP00000078618.2, ENSRNOT00000094973.2

  2. NM_001412818.1 → NP_001399747.1  E3 ubiquitin-protein ligase UBR2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I5YBG5
    Related
    ENSRNOP00000076741.1, ENSRNOT00000111742.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    21480058..21559936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083820.2 → XP_038939748.1  E3 ubiquitin-protein ligase UBR2 isoform X4

    Conserved Domains (2) summary
    pfam02207
    Location:99 → 166
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam02617
    Location:222 → 300
    ClpS; ATP-dependent Clp protease adaptor protein ClpS

  2. XM_063267357.1 → XP_063123427.1  E3 ubiquitin-protein ligase UBR2 isoform X5

  3. XM_039083816.2 → XP_038939744.1  E3 ubiquitin-protein ligase UBR2 isoform X1

    UniProtKB/TrEMBL
    D5MTH0
    Conserved Domains (5) summary
    cd00162
    Location:1113 → 1218
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    pfam02207
    Location:99 → 166
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam02617
    Location:222 → 300
    ClpS; ATP-dependent Clp protease adaptor protein ClpS
    pfam18995
    Location:1315 → 1735
    PRT6_C; Proteolysis_6 C-terminal
    cl17238
    Location:1112 → 1227
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  4. XM_063267355.1 → XP_063123425.1  E3 ubiquitin-protein ligase UBR2 isoform X2

  5. XM_063267356.1 → XP_063123426.1  E3 ubiquitin-protein ligase UBR2 isoform X3

RNA

  1. XR_010054612.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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