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Gtpbp2 GTP binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363195, updated on 10-Oct-2024

Summary

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Official Symbol
Gtpbp2provided by RGD
Official Full Name
GTP binding protein 2provided by RGD
Primary source
RGD:1306367
See related
EnsemblRapid:ENSRNOG00000019332 AllianceGenome:RGD:1306367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process, no-go decay and rescue of stalled ribosome. Orthologous to human GTPBP2 (GTP binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 105.5), Lung (RPKM 72.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gtpbp2 in Genome Data Viewer
Location:
9q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22311532..22321405, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14813964..14823419, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17198957..17208456, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene exportin 5 Neighboring gene DNA polymerase eta Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene ribosomal protein S2, pseudogene 6 Neighboring gene MAD2L1 binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Ishimura R, et al. Science, 2014 Jul 25. PMID 25061210, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-aminoacyl-tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables translation elongation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, no-go decay ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTP-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013225.2 → NP_001013243.2  GTP-binding protein 2

    See identical proteins and their annotated locations for NP_001013243.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K9J3, A6JIT1, D4ABV1
    Related
    ENSRNOP00000026195.5, ENSRNOT00000026195.8
    Conserved Domains (1) summary
    COG5258
    Location:59 → 588
    GTPBP1; GTPase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    22311532..22321405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244543.5 → XP_006244605.1  GTP-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJA2
    Related
    ENSRNOP00000093692.2, ENSRNOT00000104572.2
    Conserved Domains (1) summary
    COG5258
    Location:28 → 561
    GTPBP1; GTPase [General function prediction only]

  2. XM_063267360.1 → XP_063123430.1  GTP-binding protein 2 isoform X1

  3. XM_039083823.2 → XP_038939751.1  GTP-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZWL9
    Related
    ENSRNOP00000083263.2, ENSRNOT00000094924.2
    Conserved Domains (2) summary
    cd04165
    Location:174 → 394
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    COG5258
    Location:59 → 541
    GTPBP1; GTPase [General function prediction only]

  4. XM_017596507.3 → XP_017451996.1  GTP-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K9J3, A6JIT2
    Conserved Domains (1) summary
    COG5258
    Location:1 → 500
    GTPBP1; GTPase [General function prediction only]

  5. XM_006244545.5 → XP_006244607.1  GTP-binding protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006244607.1

    UniProtKB/TrEMBL
    A0A0G2K9J3, A6JIT2
    Conserved Domains (1) summary
    COG5258
    Location:1 → 500
    GTPBP1; GTPase [General function prediction only]

  6. XM_039083824.2 → XP_038939752.1  GTP-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    A6JIT3
    Conserved Domains (3) summary
    cd04165
    Location:23 → 243
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    cd03694
    Location:258 → 344
    GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
    cd03708
    Location:350 → 437
    GTPBP_III; Domain III of the GP-1 family of GTPases

RNA

  1. XR_005488932.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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