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Tmem63b transmembrane protein 63B [ Rattus norvegicus (Norway rat) ]

Gene ID: 363197, updated on 10-Jul-2024

Summary

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Official Symbol
Tmem63bprovided by RGD
Official Full Name
transmembrane protein 63Bprovided by RGD
Primary source
RGD:1305862
See related
EnsemblRapid:ENSRNOG00000019743 AllianceGenome:RGD:1305862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305862; Tmem63b-ps1
Summary
Predicted to enable calcium activated cation channel activity; mechanosensitive ion channel activity; and osmolarity-sensing cation channel activity. Predicted to be involved in cation transmembrane transport. Predicted to be located in actin cytoskeleton. Predicted to be active in plasma membrane. Orthologous to human TMEM63B (transmembrane protein 63B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 183.7), Adrenal (RPKM 143.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem63b in Genome Data Viewer
Location:
9q12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22810753..22838163)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (15313867..15340722)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17698697..17725479)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550363 Neighboring gene uncharacterized LOC103690501 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene calpain 11 Neighboring gene myomixer, myoblast fusion factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of Osmosensitive Ca(2+)-Permeable Channel TMEM63B Promotes Migration in HEK293T Cells. Marques MC, et al. Biochemistry, 2019 Jul 2. PMID 31243992
  2. Co-expression of mouse TMEM63A, TMEM63B and TMEM63C confers hyperosmolarity activated ion currents in HEK293 cells. Zhao X, et al. Cell Biochem Funct, 2016 Jun. PMID 27045885
  3. OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels. Murthy SE, et al. Elife, 2018 Nov 1. PMID 30382938, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables mechanosensitive monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables mechanosensitive monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables osmolarity-sensing monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in alveolar lamellar body membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CSC1-like protein 2
Names
transmembrane protein 63B, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427713.1 → NP_001414642.1  CSC1-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6GGL9, D4A105

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    22810753..22838163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267361.1 → XP_063123431.1  CSC1-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GGL9, D4A105

  2. XM_006244582.4 → XP_006244644.1  CSC1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006244644.1

    UniProtKB/TrEMBL
    A0A8I5ZKC7, A0A8I6GGL9
    Related
    ENSRNOP00000077670.1, ENSRNOT00000096202.2
    Conserved Domains (3) summary
    pfam02714
    Location:420 → 691
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52 → 208
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:227 → 409
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  3. XM_039084826.2 → XP_038940754.1  CSC1-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZKC7, A0A8I6GGL9
    Conserved Domains (3) summary
    pfam02714
    Location:420 → 691
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52 → 208
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:227 → 409
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

  4. XM_039084824.2 → XP_038940752.1  CSC1-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GGL9, D4A105
    Related
    ENSRNOP00000026728.3, ENSRNOT00000026728.6
    Conserved Domains (3) summary
    pfam02714
    Location:433 → 704
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52 → 221
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:240 → 422
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
Nucleotide Protein Strain
Heading Accession and Version

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