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INPP5A inositol polyphosphate-5-phosphatase A [ Homo sapiens (human) ]

Gene ID: 3632, updated on 2-Nov-2024

Summary

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Official Symbol
INPP5Aprovided by HGNC
Official Full Name
inositol polyphosphate-5-phosphatase Aprovided by HGNC
Primary source
HGNC:HGNC:6076
See related
Ensembl:ENSG00000068383 MIM:600106; AllianceGenome:HGNC:6076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5PTASE
Summary
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 7.6), testis (RPKM 4.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See INPP5A in Genome Data Viewer
Location:
10q26.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (132537787..132783480)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (133486789..133732662)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134351291..134596984)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134278755-134279345 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134290270-134290870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134290871-134291472 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134293876-134294475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134312545-134313046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134313047-134313546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134318393-134319092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:134319093-134319792 Neighboring gene uncharacterized LOC107984282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134329666-134330173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134330174-134330682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134330683-134331190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134331699-134332206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134341290-134341790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134354248-134354782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134354783-134355317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134358889-134359475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134359476-134360063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134364355-134365095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134363612-134364354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134368819-134369319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4229 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134383840-134384610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134385380-134386149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134386150-134386918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134386919-134387688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134387689-134388458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134389229-134389997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134388459-134389228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4235 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134421607-134422108 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:134435556-134436755 Neighboring gene VISTA enhancer hs1763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134447817-134448326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134457392-134457911 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134457912-134458430 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:134479264-134480463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134500796-134501540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134523253-134523753 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134547759-134547916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134548289-134548940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134557071-134557606 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134558117-134558298 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:134559215-134559750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134562014-134562722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134562723-134563429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134602203-134602997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134605509-134606010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134618799-134619300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134621641-134622614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134630880-134631380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134631381-134631881 Neighboring gene NK6 homeobox 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134639797-134640296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134649804-134650334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134650335-134650865 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134650866-134651395 Neighboring gene uncharacterized LOC105378571 Neighboring gene cilia and flagella associated protein 46 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134671704-134672235 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134672236-134672766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134675086-134675618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134675619-134676150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134676151-134676683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134676684-134677215 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134702122-134702650 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:134705471-134706670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134717884-134718384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134725531-134726338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134726339-134727144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134751137-134751864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134751865-134752590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134755387-134755970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134755971-134756554 Neighboring gene uncharacterized LOC105378572 Neighboring gene long intergenic non-protein coding RNA 1166

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma. Sekulic A, et al. Cancer Prev Res (Phila), 2010 Oct. PMID 20876729, Free PMC Article
  2. Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization. Mitchell CA, et al. Genomics, 1996 Jan 1. PMID 8808294
  3. Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells. De Smedt F, et al. FEBS Lett, 1994 Jun 20. PMID 8013665
  4. Post-translational modification of human brain type I inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation. De Smedt F, et al. J Biol Chem, 1996 Apr 26. PMID 8626616
  5. Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. Lee SH, et al. Mamm Genome, 2001 Feb. PMID 11210186

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ataxic phenotype and characteristics neurodegeneration of the Inpp5a Gt(OST50073)Lex mouse indicate a crucial role for Inpp5a in purkinje cells survival.
    Title: Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice.
  2. NPP5Amay play a role in development and progression of cutaneous squamous cell carcinoma tumors
    Title: Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC116947, MGC116949, DKFZp434A1721

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PH domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,4,5-trisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
  
enables inositol-polyphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-polyphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-polyphosphate 5-phosphatase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in inositol phosphate metabolic process TAS
Traceable Author Statement
more info
  
involved_in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
inositol polyphosphate-5-phosphatase A
Names
43 kDa inositol polyphosphate 5-phophatase
43 kDa inositol polyphosphate 5-phosphatase
CTCL tumor antigen HD-CL-02
InsP3 5-phosphatase
inositol polyphosphate-5-phosphatase, 40kD
inositol polyphosphate-5-phosphatase, 40kDa
inositol trisphosphate-5-phosphatase, 40kD
type I inositol 1,4,5-trisphosphate 5-phosphatase
type I inositol-1,4,5-trisphosphate 5-phophatase
NP_001307971.1
NP_005530.3
XP_016871693.1
XP_016871694.1
XP_054221771.1
XP_054221772.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321042.2 → NP_001307971.1  inositol polyphosphate-5-phosphatase A isoform b

    Status: REVIEWED

    Source sequence(s)
    AL392043, BC096280, BI964266, Z31695
    UniProtKB/TrEMBL
    Q9C055
    Conserved Domains (1) summary
    cl00490
    Location:39 → 330
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. NM_005539.5 → NP_005530.3  inositol polyphosphate-5-phosphatase A isoform a

    See identical proteins and their annotated locations for NP_005530.3

    Status: REVIEWED

    Source sequence(s)
    AL392043, BC096280, BI964266, HY025461, Z31695
    Consensus CDS
    CCDS7669.2
    UniProtKB/Swiss-Prot
    D3DXI3, Q14640, Q14642, Q5JSF1
    UniProtKB/TrEMBL
    Q4VAR4
    Related
    ENSP00000357583.3, ENST00000368594.8
    Conserved Domains (1) summary
    cd09092
    Location:10 → 394
    INPP5A; Type I inositol polyphosphate 5-phosphatase I

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    132537787..132783480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016205.2 → XP_016871694.1  inositol polyphosphate-5-phosphatase A isoform X2

    Conserved Domains (1) summary
    cl00490
    Location:10 → 301
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. XM_017016204.2 → XP_016871693.1  inositol polyphosphate-5-phosphatase A isoform X1

    UniProtKB/TrEMBL
    Q9C055
    Conserved Domains (1) summary
    cl00490
    Location:45 → 336
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RNA

  1. XR_001747104.2 RNA Sequence

  2. XR_945735.2 RNA Sequence

  3. XR_007061963.1 RNA Sequence

  4. XR_007061962.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    133486789..133732662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365797.1 → XP_054221772.1  inositol polyphosphate-5-phosphatase A isoform X2

  2. XM_054365796.1 → XP_054221771.1  inositol polyphosphate-5-phosphatase A isoform X1

RNA

  1. XR_008488213.1 RNA Sequence

  2. XR_008488212.1 RNA Sequence

  3. XR_008488211.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14642.1 GenPept UniProtKB/Swiss-Prot:Q14642

Gene LinkOut

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