U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cnnm4 cyclin and CBS domain divalent metal cation transport mediator 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363216, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Cnnm4provided by RGD
Official Full Name
cyclin and CBS domain divalent metal cation transport mediator 4provided by RGD
Primary source
RGD:1305571
See related
EnsemblRapid:ENSRNOG00000015886 AllianceGenome:RGD:1305571
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable magnesium ion transmembrane transporter activity and sodium ion transmembrane transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis; magnesium ion homeostasis; and magnesium ion transport. Predicted to act upstream of or within enamel mineralization. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in Jalili syndrome. Orthologous to human CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 71.5), Kidney (RPKM 53.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cnnm4 in Genome Data Viewer
Location:
9q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46207602..46246817)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38711726..38750942)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43049587..43088690)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene fer-1-like family member 5 Neighboring gene lectin, mannose-binding 2-like Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 3 Neighboring gene ankyrin repeat domain 23

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model. Yamazaki D, et al. PLoS Genet, 2013. PMID 24339795, Free PMC Article
  2. Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis. Guo D, et al. Mol Pain, 2005 Apr 19. PMID 15840172, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in enamel mineralization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enamel mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular monoatomic cation homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular monoatomic cation homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in magnesium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within magnesium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in magnesium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within magnesium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
metal transporter CNNM4
Names
ancient conserved domain-containing protein 4
cyclin-M4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271050.1 → NP_001257979.1  metal transporter CNNM4 precursor

    See identical proteins and their annotated locations for NP_001257979.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P0C588
    UniProtKB/TrEMBL
    A6IND6
    Related
    ENSRNOP00000021434.4, ENSRNOT00000021434.9
    Conserved Domains (3) summary
    COG0517
    Location:371 → 498
    CBS; CBS domain [Signal transduction mechanisms]
    cd04590
    Location:380 → 500
    CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
    pfam01595
    Location:194 → 356
    DUF21; Domain of unknown function DUF21

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    46207602..46246817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596510.3 → XP_017451999.1  metal transporter CNNM4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYC2, A6IND6
    Related
    ENSRNOP00000070598.2, ENSRNOT00000079234.3

  2. XM_039083840.2 → XP_038939768.1  metal transporter CNNM4 isoform X2

    UniProtKB/TrEMBL
    A6IND6
    Conserved Domains (1) summary
    COG1253
    Location:194 → 521
    TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

  3. XM_006244827.5 → XP_006244889.2  metal transporter CNNM4 isoform X3

    UniProtKB/TrEMBL
    A6IND6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C588.1 GenPept UniProtKB/Swiss-Prot:P0C588

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools