U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363239, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Raph1provided by RGD
Official Full Name
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1provided by RGD
Primary source
RGD:1308387
See related
EnsemblRapid:ENSRNOG00000014722 AllianceGenome:RGD:1308387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in signal transduction. Predicted to act upstream of or within axon extension. Predicted to be located in cell leading edge and nuclear body. Predicted to be active in cytosol and plasma membrane. Orthologous to human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 138.8), Liver (RPKM 131.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Raph1 in Genome Data Viewer
Location:
9q32
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (69397272..69484174, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61907476..61990170, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (67290004..67370208, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit c locus 2, pseudogene 1 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene abl-interactor 2 Neighboring gene uncharacterized LOC102547711 Neighboring gene small nucleolar RNA SNORA51

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis. Michael M, et al. Curr Biol, 2010 May 11. PMID 20417104, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ras-associated and pleckstrin homology domains-containing protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108798.2 → NP_001102268.2  ras-associated and pleckstrin homology domains-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I5ZU51
    Related
    ENSRNOP00000081933.2, ENSRNOT00000102881.2
    Conserved Domains (3) summary
    cd01259
    Location:393 → 515
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:398 → 506
    PH; PH domain
    cl00155
    Location:270 → 351
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    69397272..69484174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267382.1 → XP_063123452.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X12

  2. XM_063267381.1 → XP_063123451.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X11

  3. XM_039083870.2 → XP_038939798.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    D4ADX8
    Conserved Domains (2) summary
    cd01259
    Location:445 → 567
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:320 → 409
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  4. XM_039083868.2 → XP_038939796.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AMM7, A6IPC9
    Related
    ENSRNOP00000033491.7, ENSRNOT00000036194.8
    Conserved Domains (2) summary
    cd01259
    Location:445 → 567
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:320 → 409
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  5. XM_039083863.2 → XP_038939791.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZL54
    Related
    ENSRNOP00000078550.1, ENSRNOT00000106942.2
    Conserved Domains (2) summary
    cd01259
    Location:418 → 540
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:293 → 382
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  6. XM_039083862.2 → XP_038939790.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AF23
    Related
    ENSRNOP00000093050.1, ENSRNOT00000110139.2
    Conserved Domains (2) summary
    cd01259
    Location:420 → 542
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:295 → 384
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  7. XM_039083861.2 → XP_038939789.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A272
    Related
    ENSRNOP00000084951.1, ENSRNOT00000119642.2
    Conserved Domains (2) summary
    cd01259
    Location:445 → 567
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:320 → 409
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  8. XM_063267379.1 → XP_063123449.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X8

  9. XM_063267380.1 → XP_063123450.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X10

  10. XM_039083864.2 → XP_038939792.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X4

    Conserved Domains (2) summary
    cd01259
    Location:384 → 506
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:259 → 348
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  11. XM_039083866.1 → XP_038939794.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X5

  12. XM_039083869.2 → XP_038939797.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    D4ADX8
    Conserved Domains (2) summary
    cd01259
    Location:445 → 567
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:320 → 409
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

RNA

  1. XR_005488933.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools