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Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363255, updated on 2-Nov-2024

Summary

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Official Symbol
Ankzf1provided by RGD
Official Full Name
ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1provided by RGD
Primary source
RGD:1359242
See related
EnsemblRapid:ENSRNOG00000019052 AllianceGenome:RGD:1359242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1359242
Summary
Predicted to enable RNA endonuclease activity and catalytic activity, acting on a tRNA. Predicted to be involved in cellular response to hydrogen peroxide; proteolysis involved in protein catabolic process; and rescue of stalled ribosome. Predicted to be located in cytoplasm. Orthologous to human ANKZF1 (ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 167.3), Adrenal (RPKM 146.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ankzf1 in Genome Data Viewer
Location:
9q33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84136862..84143830)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76688194..76695162)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82393619..82400537)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 6 Neighboring gene autophagy related 9A Neighboring gene galactosidase, beta 1-like Neighboring gene serine/threonine kinase 16 Neighboring gene uncharacterized LOC102554903 Neighboring gene tubulin, alpha 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ankyrin repeat and zinc-finger domain-containing 1 mutations are associated with infantile-onset inflammatory bowel disease. van Haaften-Visser DY, et al. J Biol Chem, 2017 May 12. PMID 28302725, Free PMC Article
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a tRNA ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity, acting on a tRNA ISS
Inferred from Sequence or Structural Similarity
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins IEA
Inferred from Electronic Annotation
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rescue of stalled ribosome IEA
Inferred from Electronic Annotation
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tRNA endonuclease ANKZF1
Names
ankyrin repeat and zinc finger domain containing 1
ankyrin repeat and zinc finger domain-containing protein 1
ankyrin repeat containing protein RGD1359242

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014219.2 → NP_001014241.2  tRNA endonuclease ANKZF1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q66H85
    UniProtKB/TrEMBL
    A0A8L2QKJ1, A6JVY8
    Related
    ENSRNOP00000036500.6, ENSRNOT00000032419.6
    Conserved Domains (8) summary
    PTZ00322
    Location:557 → 629
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    smart00451
    Location:95 → 127
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:98 → 120
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00045
    Location:517 → 547
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:557 → 587
    Ank; Ankyrin repeat
    pfam12796
    Location:520 → 587
    Ank_2; Ankyrin repeats (3 copies)
    pfam18716
    Location:705 → 746
    VATC; Vms1-associating treble clef domain
    pfam18826
    Location:231 → 375
    bVLRF1; bacteroidetes VLRF1 release factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    84136862..84143830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267411.1 → XP_063123481.1  tRNA endonuclease ANKZF1 isoform X2

  2. XM_006245248.3 → XP_006245310.1  tRNA endonuclease ANKZF1 isoform X1

    UniProtKB/Swiss-Prot
    Q66H85
    Related
    ENSRNOP00000111906.1, ENSRNOT00000139430.1
    Conserved Domains (4) summary
    cd00204
    Location:505 → 567
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00020
    Location:98 → 120
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13857
    Location:484 → 545
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:465 → 495
    ANK; ANK repeat [structural motif]

RNA

  1. XR_005488937.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H85.1 GenPept UniProtKB/Swiss-Prot:Q66H85

Gene LinkOut

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