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Ube2f ubiquitin-conjugating enzyme E2F (putative) [ Rattus norvegicus (Norway rat) ]

Gene ID: 363284, updated on 6-Jun-2024

Summary

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Official Symbol
Ube2fprovided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2F (putative)provided by RGD
Primary source
RGD:1307608
See related
Ensembl:ENSRNOG00000019953 AllianceGenome:RGD:1307608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307608
Summary
Predicted to enable NEDD8 conjugating enzyme activity. Predicted to be involved in protein neddylation. Predicted to be active in nucleus. Orthologous to human UBE2F (ubiquitin conjugating enzyme E2 F (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 198.3), Kidney (RPKM 153.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ube2f in Genome Data Viewer
Location:
9q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99293506..99328690)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (91845975..91881145)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98394112..98428684)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene receptor activity modifying protein 1 Neighboring gene pyruvate kinase M1/2, pseudogene 10 Neighboring gene selenocysteine lyase Neighboring gene espin-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Huang DT, et al. Mol Cell, 2009 Feb 27. PMID 19250909, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105540

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NEDD8 conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables NEDD8 conjugating enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NEDD8 ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables NEDD8 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NEDD8 transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables NEDD8 transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein neddylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein neddylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NEDD8-conjugating enzyme UBE2F
Names
NEDD8 carrier protein UBE2F
NEDD8 protein ligase UBE2F
RING-type E3 NEDD8 transferase UBE2F
ubiquitin-conjugating enzyme E2 F
NP_001008382.1
NP_001386083.1
NP_001386084.1
NP_001386085.1
NP_001386086.1
NP_001386087.1
NP_001386088.1
NP_001386101.1
XP_006245485.1
XP_017452028.1
XP_038939848.1
XP_063123523.1
XP_063123524.1
XP_063123525.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008381.2 → NP_001008382.1  NEDD8-conjugating enzyme UBE2F isoform 3

    See identical proteins and their annotated locations for NP_001008382.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6ALE6
    Related
    ENSRNOP00000040354.2, ENSRNOT00000042082.5
    Conserved Domains (2) summary
    smart00212
    Location:49 → 162
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    COG5078
    Location:30 → 162
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

  2. NM_001399154.1 → NP_001386083.1  NEDD8-conjugating enzyme UBE2F isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5U203
    UniProtKB/TrEMBL
    A0A8I6ALE6, A6JQQ2
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_001399155.1 → NP_001386084.1  NEDD8-conjugating enzyme UBE2F isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5U203
    UniProtKB/TrEMBL
    A0A8I6ALE6, A6JQQ2
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  4. NM_001399156.1 → NP_001386085.1  NEDD8-conjugating enzyme UBE2F isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5U203
    UniProtKB/TrEMBL
    A0A8I6ALE6, A6JQQ2
    Related
    ENSRNOP00000080917.1, ENSRNOT00000100973.1
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  5. NM_001399157.1 → NP_001386086.1  NEDD8-conjugating enzyme UBE2F isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6ALE6, A6JQQ3
    Related
    ENSRNOP00000094106.1, ENSRNOT00000116409.1
    Conserved Domains (1) summary
    cl00154
    Location:61 → 174
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  6. NM_001399158.1 → NP_001386087.1  NEDD8-conjugating enzyme UBE2F isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6ALE6
    Conserved Domains (1) summary
    cl00154
    Location:40 → 152
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  7. NM_001399159.1 → NP_001386088.1  NEDD8-conjugating enzyme UBE2F isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6ALE6
    Conserved Domains (1) summary
    cl00154
    Location:40 → 152
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  8. NM_001399172.1 → NP_001386101.1  NEDD8-conjugating enzyme UBE2F isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    99293506..99328690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267454.1 → XP_063123524.1  NEDD8-conjugating enzyme UBE2F isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALE6, A6JQQ3

  2. XM_063267455.1 → XP_063123525.1  NEDD8-conjugating enzyme UBE2F isoform X3

    UniProtKB/TrEMBL
    A0A8I6ALE6

  3. XM_017596539.3 → XP_017452028.1  NEDD8-conjugating enzyme UBE2F isoform X1

    UniProtKB/Swiss-Prot
    Q5U203
    UniProtKB/TrEMBL
    A0A8I6ALE6, A6JQQ2
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  4. XM_063267453.1 → XP_063123523.1  NEDD8-conjugating enzyme UBE2F isoform X1

    UniProtKB/Swiss-Prot
    Q5U203
    UniProtKB/TrEMBL
    A0A8I6ALE6, A6JQQ2

  5. XM_006245423.5 → XP_006245485.1  NEDD8-conjugating enzyme UBE2F isoform X1

    See identical proteins and their annotated locations for XP_006245485.1

    UniProtKB/Swiss-Prot
    Q5U203
    UniProtKB/TrEMBL
    A0A8I6ALE6, A6JQQ2
    Related
    ENSRNOP00000027050.4
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  6. XM_039083920.2 → XP_038939848.1  NEDD8-conjugating enzyme UBE2F isoform X1

    UniProtKB/Swiss-Prot
    Q5U203
    UniProtKB/TrEMBL
    A0A8I6ALE6, A6JQQ2
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U203.2 GenPept UniProtKB/Swiss-Prot:Q5U203

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