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Thap4 THAP domain containing 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363291, updated on 17-Aug-2024

Summary

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Official Symbol
Thap4provided by RGD
Official Full Name
THAP domain containing 4provided by RGD
Primary source
RGD:1359473
See related
EnsemblRapid:ENSRNOG00000018351 AllianceGenome:RGD:1359473
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nb(III)
Summary
Predicted to enable several functions, including heme binding activity; identical protein binding activity; and peroxynitrite isomerase activity. Predicted to be involved in nitrate metabolic process and tyrosine metabolic process. Orthologous to human THAP4 (THAP domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 101.9), Adrenal (RPKM 85.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Thap4 in Genome Data Viewer
Location:
9q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101689935..101729656, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94242581..94282312, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100848597..100888107, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 25 Neighboring gene BCL2 family apoptosis regulator BOK Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene deoxythymidylate kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of the C-terminal heme-binding domain of THAP domain containing protein 4 from Homo sapiens. Bianchetti CM, et al. Proteins, 2011 Apr. PMID 21387410, Free PMC Article
  2. Human nitrobindin: the first example of an all-β-barrel ferric heme-protein that catalyzes peroxynitrite detoxification. De Simone G, et al. FEBS Open Bio, 2018 Dec. PMID 30524950, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.
    Title: Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93755

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nitric oxide binding ISO
Inferred from Sequence Orthology
more info
  
enables nitric oxide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peroxynitrite isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables peroxynitrite isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in nitrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nitrate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tyrosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tyrosine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxynitrite isomerase THAP4
Names
THAP domain-containing protein 4
ferric nitrobindin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005564.1 → NP_001005564.1  peroxynitrite isomerase THAP4

    See identical proteins and their annotated locations for NP_001005564.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081882
    UniProtKB/Swiss-Prot
    Q642B6
    UniProtKB/TrEMBL
    A0A8I6ANL8, A6JR27
    Related
    ENSRNOP00000024794.4, ENSRNOT00000024794.6
    Conserved Domains (2) summary
    pfam05485
    Location:4 → 86
    THAP; THAP domain
    pfam08768
    Location:414 → 566
    DUF1794; Domain of unknown function (DUF1794)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    101689935..101729656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083932.2 → XP_038939860.1  peroxynitrite isomerase THAP4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ANL8
    Conserved Domains (4) summary
    PHA03377
    Location:138 → 322
    PHA03377; EBNA-3C; Provisional
    smart00980
    Location:4 → 85
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
    pfam09486
    Location:342 → 389
    HrpB7; Bacterial type III secretion protein (HrpB7)
    cd07828
    Location:414 → 501
    lipocalin_heme-bd-THAP4-like; heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins

  2. XM_008767380.4 → XP_008765602.1  peroxynitrite isomerase THAP4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBX9
    Conserved Domains (1) summary
    pfam08768
    Location:60 → 212
    DUF1794; Domain of unknown function (DUF1794)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q642B6.1 GenPept UniProtKB/Swiss-Prot:Q642B6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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