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Snx12 sorting nexin 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363478, updated on 2-Nov-2024

Summary

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Official Symbol
Snx12provided by RGD
Official Full Name
sorting nexin 12provided by RGD
Primary source
RGD:1565585
See related
EnsemblRapid:ENSRNOG00000004036 AllianceGenome:RGD:1565585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565585
Summary
Predicted to enable enzyme binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in several processes, including endosomal transport; negative regulation of protein metabolic process; and regulation of vesicle-mediated transport. Predicted to be located in early endosome. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Orthologous to human SNX12 (sorting nexin 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 121.3), Brain (RPKM 94.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Snx12 in Genome Data Viewer
Location:
Xq22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (70267013..70396948, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (66226995..66356945, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (70989822..71127330, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene testis expressed 11 Neighboring gene glutamyl-tRNA amidotransferase subunit C, pseudogene 1 Neighboring gene solute carrier family 7 member 3 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene ribosomal protein S2, pseudogene 24 Neighboring gene uncharacterized LOC102548326 Neighboring gene forkhead box O4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing. Zhao Y, et al. Mol Neurodegener, 2012 Jun 18. PMID 22709416, Free PMC Article
  2. SNX12 role in endosome membrane transport. Pons V, et al. PLoS One, 2012. PMID 22719997, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sorting nexin-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108817.2 → NP_001102287.2  sorting nexin-12

    See identical proteins and their annotated locations for NP_001102287.2

    Status: VALIDATED

    Source sequence(s)
    BP500254
    UniProtKB/TrEMBL
    A0A096MJN6
    Conserved Domains (1) summary
    cd07294
    Location:27 → 158
    PX_SNX12; The phosphoinositide binding Phox Homology domain of Sorting Nexin 12

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    70267013..70396948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099898.2 → XP_038955826.1  sorting nexin-12 isoform X1

    UniProtKB/TrEMBL
    A0A096MJN6
    Conserved Domains (1) summary
    cd07294
    Location:27 → 158
    PX_SNX12; The phosphoinositide binding Phox Homology domain of Sorting Nexin 12

  2. XM_039099899.2 → XP_038955827.1  sorting nexin-12 isoform X6

    UniProtKB/TrEMBL
    A0A096MJN6
    Conserved Domains (1) summary
    cd07294
    Location:27 → 158
    PX_SNX12; The phosphoinositide binding Phox Homology domain of Sorting Nexin 12

  3. XM_017602108.3 → XP_017457597.1  sorting nexin-12 isoform X2

    UniProtKB/TrEMBL
    A0A096MJN6

  4. XM_063280145.1 → XP_063136215.1  sorting nexin-12 isoform X4

  5. XM_063280144.1 → XP_063136214.1  sorting nexin-12 isoform X3

    UniProtKB/TrEMBL
    D4A719
    Related
    ENSRNOP00000068200.3, ENSRNOT00000076635.4

  6. XM_006257079.4 → XP_006257141.2  sorting nexin-12 isoform X5

    UniProtKB/TrEMBL
    A0A096MJN6
    Conserved Domains (1) summary
    cd07294
    Location:27 → 158
    PX_SNX12; The phosphoinositide binding Phox Homology domain of Sorting Nexin 12
Nucleotide Protein Strain
Heading Accession and Version

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