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Taf7l TATA-box binding protein associated factor 7-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 363493, updated on 2-Nov-2024

Summary

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Official Symbol
Taf7lprovided by RGD
Official Full Name
TATA-box binding protein associated factor 7-likeprovided by RGD
Primary source
RGD:1564898
See related
EnsemblRapid:ENSRNOG00000026315 AllianceGenome:RGD:1564898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564898
Summary
Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to act upstream of or within flagellated sperm motility and spermatid development. Predicted to be located in cytoplasm and male germ cell nucleus. Predicted to be part of transcription factor TFIID complex. Orthologous to human TAF7L (TATA-box binding protein associated factor 7 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 101.2) See more
Orthologs
human mouse all
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Genomic context

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See Taf7l in Genome Data Viewer
Location:
Xq32
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (101953508..101968336, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97660222..97675241, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105292338..105308554, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene centromere protein I Neighboring gene dystrophin related protein 2 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA aspartic acid (anticodon AUC) 1 Neighboring gene translocase of inner mitochondrial membrane 8A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TAF7L regulates early stages of male germ cell development in the rat. Moreno-Irusta A, et al. FASEB J, 2024 Jan. PMID 38112167, Free PMC Article
  2. Abnormal sperm in mice lacking the Taf7l gene. Cheng Y, et al. Mol Cell Biol, 2007 Apr. PMID 17242199, Free PMC Article
  3. Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells. Catena R, et al. FEBS Lett, 2005 Jun 20. PMID 15927180
  4. The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. Pointud JC, et al. J Cell Sci, 2003 May 1. PMID 12665565
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAF7L regulates early stages of male germ cell development in the rat.
    Title: TAF7L regulates early stages of male germ cell development in the rat.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
NOT located_in chromocenter ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 7-like
Names
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001434284.1 → NP_001421213.1  transcription initiation factor TFIID subunit 7-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  2. NM_001434285.1 → NP_001421214.1  transcription initiation factor TFIID subunit 7-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    101953508..101968336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099902.2 → XP_038955830.1  transcription initiation factor TFIID subunit 7-like isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZWV0, A6IVF5
    Related
    ENSRNOP00000083355.1, ENSRNOT00000102985.2
    Conserved Domains (1) summary
    pfam04658
    Location:123 → 302
    TAFII55_N; TAFII55 protein conserved region

  2. XM_039099903.2 → XP_038955831.1  transcription initiation factor TFIID subunit 7-like isoform X2

    UniProtKB/TrEMBL
    A6IVF5
    Conserved Domains (1) summary
    pfam04658
    Location:80 → 259
    TAFII55_N; TAFII55 protein conserved region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135877.1: Suppressed sequence

    Description
    NM_001135877.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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