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Naa60 N(alpha)-acetyltransferase 60, NatF catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 363545, updated on 2-Nov-2024

Summary

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Official Symbol
Naa60provided by RGD
Official Full Name
N(alpha)-acetyltransferase 60, NatF catalytic subunitprovided by RGD
Primary source
RGD:1308915
See related
EnsemblRapid:ENSRNOG00000007280 AllianceGenome:RGD:1308915
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HAT4; NatF; Nat15; RGD1308915
Summary
Predicted to enable histone H4 acetyltransferase activity; peptide alpha-N-acetyltransferase activity; and protein homodimerization activity. Predicted to be involved in several processes, including N-terminal peptidyl-methionine acetylation; chromosome segregation; and nucleosome assembly. Predicted to be active in Golgi membrane. Orthologous to human NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 117.2), Brain (RPKM 111.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Naa60 in Genome Data Viewer
Location:
10q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (12129026..12149053, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11622554..11653078, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11881635..11902139, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene NLR family, CARD domain containing 3 Neighboring gene clusterin associated protein 1 Neighboring gene similar to human chromosome 16 open reading frame 90 Neighboring gene zinc finger protein 597 Neighboring gene zinc finger protein 174

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase. Chen JY, et al. Sci Rep, 2016 Aug 23. PMID 27550639, Free PMC Article
  2. Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation. Støve SI, et al. Structure, 2016 Jul 6. PMID 27320834, Free PMC Article
  3. HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Yang X, et al. Mol Cell, 2011 Oct 7. PMID 21981917
  4. NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. Van Damme P, et al. PLoS Genet, 2011 Jul. PMID 21750686, Free PMC Article
  5. An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. Aksnes H, et al. Cell Rep, 2015 Mar 3. PMID 25732826

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124897

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H4 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide alpha-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide alpha-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide alpha-N-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide-methionine-alpha-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in N-terminal peptidyl-methionine acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in N-terminal peptidyl-methionine acetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in N-terminal protein amino acid acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in N-terminal protein amino acid acetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 60
Names
GNAT acetyltransferase
GNAT acetytransferase
N-acetyltransferase 15 (GCN5-related, putative)
N-alpha-acetyltransferase F
histone acetyltransferase type B protein 4
natF catalytic subunit
NP_001014248.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014226.2 → NP_001014248.2  N-alpha-acetyltransferase 60

    See identical proteins and their annotated locations for NP_001014248.2

    Status: PROVISIONAL

    Source sequence(s)
    BC105304
    UniProtKB/Swiss-Prot
    Q3MHC1, Q7TMZ6
    Related
    ENSRNOP00000009936.3, ENSRNOT00000009936.8
    Conserved Domains (2) summary
    pfam00583
    Location:23 → 155
    Acetyltransf_1; Acetyltransferase (GNAT) family
    cl21457
    Location:139 → 203
    TIM; TIM-like beta/alpha barrel domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    12129026..12149053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3MHC1.1 GenPept UniProtKB/Swiss-Prot:Q3MHC1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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