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INPPL1 inositol polyphosphate phosphatase like 1 [ Homo sapiens (human) ]

Gene ID: 3636, updated on 16-Apr-2024

Summary

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Official Symbol
INPPL1provided by HGNC
Official Full Name
inositol polyphosphate phosphatase like 1provided by HGNC
Primary source
HGNC:HGNC:6080
See related
Ensembl:ENSG00000165458 MIM:600829; AllianceGenome:HGNC:6080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OPSMD; SHIP2
Summary
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in placenta (RPKM 19.8), thyroid (RPKM 19.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q13.4
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72223563..72239147)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (72149924..72165764)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71935811..71950191)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene folate receptor alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3717 Neighboring gene folate receptor beta Neighboring gene skeletal muscle cis-regulatory module in INPPL1 intron Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3718 Neighboring gene paired like homeobox 2A Neighboring gene dedicator of cytokinesis 1 pseudogene Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2. Le Coq J, et al. FASEB J, 2021 Aug. PMID 34314064
  2. Expression, purification and characterization of the RhoA-binding domain of human SHIP2 in E.coli. Zhou H, et al. Protein Expr Purif, 2021 Apr. PMID 33421554
  3. Helicobacter pylori CagA oncoprotein interacts with SHIP2 to increase its delivery into gastric epithelial cells. Fujii Y, et al. Cancer Sci, 2020 May. PMID 32198795, Free PMC Article
  4. Descending-SHIP2-mediated radiosensitivity enhancement through PI3K/Akt signaling pathway in laryngeal squamous cell carcinoma. Tang T, et al. Biomed Pharmacother, 2019 Oct. PMID 31545285
  5. Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects. Ghosh S, et al. Hum Mutat, 2017 Dec. PMID 28869677

See all (158) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.
    Title: Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.
  2. PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
    Title: PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
  3. OxLDL-stimulated macrophage exosomes promote proatherogenic vascular smooth muscle cell viability and invasion via delivering miR-186-5p then inactivating SHIP2 mediated PI3K/AKT/mTOR pathway.
    Title: OxLDL-stimulated macrophage exosomes promote proatherogenic vascular smooth muscle cell viability and invasion via delivering miR-186-5p then inactivating SHIP2 mediated PI3K/AKT/mTOR pathway.
  4. An auxiliary binding interface of SHIP2-SH2 for Y292-phosphorylated FcgammaRIIB reveals diverse recognition mechanisms for tyrosine-phosphorylated receptors involved in different cell signaling pathways.
    Title: An auxiliary binding interface of SHIP2-SH2 for Y292-phosphorylated FcγRIIB reveals diverse recognition mechanisms for tyrosine-phosphorylated receptors involved in different cell signaling pathways.
  5. SHIP2 inhibition alters redox-induced PI3K/AKT and MAP kinase pathways via PTEN over-activation in cervical cancer cells.
    Title: SHIP2 inhibition alters redox-induced PI3K/AKT and MAP kinase pathways via PTEN over-activation in cervical cancer cells.
  6. IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.
    Title: IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.
  7. A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2.
    Title: A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2.
  8. Expression, purification and characterization of the RhoA-binding domain of human SHIP2 in E.coli.
    Title: Expression, purification and characterization of the RhoA-binding domain of human SHIP2 in E.coli.
  9. Phosphoinositide 5-phosphatases SKIP and SHIP2 in ruffles, the endoplasmic reticulum and the nucleus: An update.
    Title: Phosphoinositide 5-phosphatases SKIP and SHIP2 in ruffles, the endoplasmic reticulum and the nucleus: An update.
  10. IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity.
    Title: IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity.
Submit: New GeneRIF Correction See all GeneRIFs (89)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Opsismodysplasia
MedGen: C0432219 OMIM: 258480 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH2 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol-polyphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in endochondral ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
  
involved_in ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Names
51C protein
INPPL-1
SH2 domain-containing inositol-5'-phosphatase 2
SHIP-2
protein 51C
NP_001558.3
XP_005274036.1
XP_011543301.1
XP_047282843.1
XP_047282844.1
XP_047282845.1
XP_047282846.1
XP_047282847.1
XP_047282848.1
XP_047282849.1
XP_054224654.1
XP_054224655.1
XP_054224656.1
XP_054224657.1
XP_054224658.1
XP_054224659.1
XP_054224660.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023253.2 RefSeqGene

    Range
    4930..19310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001567.4 → NP_001558.3  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

    See identical proteins and their annotated locations for NP_001558.3

    Status: REVIEWED

    Source sequence(s)
    AP000593, BC140853, BG236320, Y14385
    Consensus CDS
    CCDS8213.1
    UniProtKB/Swiss-Prot
    B2RTX5, O15357, Q13577, Q13578
    Related
    ENSP00000298229.2, ENST00000298229.7
    Conserved Domains (4) summary
    cd09491
    Location:1194 → 1256
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:424 → 727
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    smart00454
    Location:1202 → 1258
    SAM; Sterile alpha motif
    cd10343
    Location:17 → 119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    72223563..72239147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426888.1 → XP_047282844.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

  2. XM_047426890.1 → XP_047282846.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

    UniProtKB/Swiss-Prot
    B2RTX5, O15357, Q13577, Q13578

  3. XM_047426887.1 → XP_047282843.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

  4. XM_005273979.5 → XP_005274036.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

    See identical proteins and their annotated locations for XP_005274036.1

    Conserved Domains (4) summary
    cd09491
    Location:1216 → 1278
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:446 → 749
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    smart00454
    Location:1224 → 1280
    SAM; Sterile alpha motif
    cd10343
    Location:17 → 119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

  5. XM_047426891.1 → XP_047282847.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X3

  6. XM_011544999.3 → XP_011543301.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

    See identical proteins and their annotated locations for XP_011543301.1

    UniProtKB/Swiss-Prot
    B2RTX5, O15357, Q13577, Q13578
    Conserved Domains (4) summary
    cd09491
    Location:1194 → 1256
    SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
    cd09101
    Location:424 → 727
    INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
    smart00454
    Location:1202 → 1258
    SAM; Sterile alpha motif
    cd10343
    Location:17 → 119
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

  7. XM_047426892.1 → XP_047282848.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4

  8. XM_047426889.1 → XP_047282845.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

  9. XM_047426893.1 → XP_047282849.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X5

    Related
    ENSP00000444619.1, ENST00000538751.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    72149924..72165764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368682.1 → XP_054224657.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

  2. XM_054368679.1 → XP_054224654.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

  3. XM_054368683.1 → XP_054224658.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X3

  4. XM_054368681.1 → XP_054224656.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

  5. XM_054368684.1 → XP_054224659.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4

  6. XM_054368680.1 → XP_054224655.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

  7. XM_054368685.1 → XP_054224660.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15357.2 GenPept UniProtKB/Swiss-Prot:O15357

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