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Stard3 StAR-related lipid transfer domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363675, updated on 19-Jun-2024

Summary

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Official Symbol
Stard3provided by RGD
Official Full Name
StAR-related lipid transfer domain containing 3provided by RGD
Primary source
RGD:1549768
See related
Ensembl:ENSRNOG00000042044 AllianceGenome:RGD:1549768
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cholesterol binding activity and protein homodimerization activity. Predicted to be involved in cholesterol transport and vesicle tethering to endoplasmic reticulum. Predicted to act upstream of or within progesterone biosynthetic process. Predicted to be located in several cellular components, including endoplasmic reticulum-endosome membrane contact site; late endosome membrane; and nucleoplasm. Predicted to colocalize with endoplasmic reticulum membrane. Orthologous to human STARD3 (StAR related lipid transfer domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 107.8), Kidney (RPKM 80.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stard3 in Genome Data Viewer
Location:
10q31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83853622..83876162)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83357329..83379873)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86313430..86335868)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene neuronal differentiation 2 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1B Neighboring gene titin-cap Neighboring gene phenylethanolamine-N-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation of cDNA clones from an osteosarcoma-ROS17/2.8 library by differential hybridization. Waye MM, et al. J Cell Biochem, 1994 Mar. PMID 8200907
  2. Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. Kishida T, et al. J Biol Chem, 2004 Apr 30. PMID 14963026
  3. STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites. Wilhelm LP, et al. EMBO J, 2017 May 15. PMID 28377464, Free PMC Article
  4. Functional characterization of the MENTAL domain. Alpy F, et al. J Biol Chem, 2005 May 6. PMID 15718238
  5. STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER. Alpy F, et al. J Cell Sci, 2013 Dec 1. PMID 24105263

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables cholesterol transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within progesterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle tethering to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle tethering to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-endosome membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-endosome membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
stAR-related lipid transfer protein 3
Names
START domain containing 3
StAR-related lipid transfer (START) domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014229.1 → NP_001014251.1  stAR-related lipid transfer protein 3

    See identical proteins and their annotated locations for NP_001014251.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085872
    UniProtKB/TrEMBL
    A0A9K3Y7H2, F1M1S3, Q5U2T5
    Related
    ENSRNOP00000059898.2, ENSRNOT00000064190.4
    Conserved Domains (2) summary
    cd08906
    Location:234 → 442
    START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins
    pfam10457
    Location:48 → 214
    MENTAL; Cholesterol-capturing domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    83853622..83876162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086506.2 → XP_038942434.1  stAR-related lipid transfer protein 3 isoform X2

    Conserved Domains (2) summary
    pfam10457
    Location:48 → 214
    MENTAL; Cholesterol-capturing domain
    cl14643
    Location:234 → 266
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  2. XM_039086505.2 → XP_038942433.1  stAR-related lipid transfer protein 3 isoform X1

    UniProtKB/TrEMBL
    A6HIR9
    Conserved Domains (2) summary
    cd08906
    Location:186 → 394
    START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins
    pfam10457
    Location:29 → 166
    MENTAL; Cholesterol-capturing domain
Nucleotide Protein Strain
Heading Accession and Version

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