Arl6 ADP-ribosylation factor like GTPase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arl6provided by RGD
Official Full Name: ADP-ribosylation factor like GTPase 6provided by RGD
Primary source: RGD:1305535
See related: EnsemblRapid:ENSRNOG00000001689 AllianceGenome:RGD:1305535
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity. Predicted to be involved in several processes, including Wnt signaling pathway; fat cell differentiation; and protein localization to non-motile cilium. Predicted to act upstream of or within several processes, including protein transport from ciliary membrane to plasma membrane; regulation of smoothened signaling pathway; and retina layer formation. Predicted to be located in several cellular components, including cilium; cytosol; and microtubule cytoskeleton. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Orthologous to human ARL6 (ADP ribosylation factor like GTPase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 89.5), Kidney (RPKM 83.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (54180271..54207136)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (40711878..40738254)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (42858476..42884324)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in protein localization to non-motile cilium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport from ciliary membrane to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina layer formation	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 6

Names: ADP-ribosylation factor-like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108842.1 → NP_001102312.1 ADP-ribosylation factor-like protein 6

Status: PROVISIONAL

Source sequence(s)

CH473967

UniProtKB/TrEMBL

A0A8J8YB99, A6IQI5

Conserved Domains (1) summary

cd04157
Location:19 → 178

Arl6; Arf-like 6 (Arl6) GTPase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

54180271..54207136

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248193.5 → XP_006248255.1 ADP-ribosylation factor-like protein 6 isoform X1

UniProtKB/TrEMBL

A0A8I6ACB6, A0A8J8YB99, B1WC73, F7F983

Related

ENSRNOP00000091133.1, ENSRNOT00000110067.2

Conserved Domains (1) summary

cd04157
Location:19 → 180

Arl6; Arf-like 6 (Arl6) GTPase