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Zdhhc23 zinc finger DHHC-type palmitoyltransferase 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363783, updated on 18-Sep-2024

Summary

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Official Symbol
Zdhhc23provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 23provided by RGD
Primary source
RGD:1303254
See related
EnsemblRapid:ENSRNOG00000060348 AllianceGenome:RGD:1303254
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
nidd; DHHC23
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to act upstream of or within protein localization to plasma membrane and protein palmitoylation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC23 (zinc finger DHHC-type palmitoyltransferase 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 47.1), Brain (RPKM 36.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zdhhc23 in Genome Data Viewer
Location:
11q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (70224581..70240971)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56718702..56735063)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61661119..61677547)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095658 Neighboring gene ATPase H+ transporting V1 subunit A Neighboring gene uncharacterized LOC134481070 Neighboring gene GRAM domain containing 1C Neighboring gene coiled-coil domain containing 191 Neighboring gene small nucleolar RNA, H/ACA box 84 Neighboring gene queuine tRNA-ribosyltransferase accessory subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NIDD mRNA was predominantly expressed in nociceptive neurons and in neurons of the spinal dorsal horn and the number of NIDD-positive neurons in the corresponding dorsal root ganglia or spinal cord increased following induction of chronic hyperalgesia.
    Title: Altered gene expression of NIDD in dorsal root ganglia and spinal cord of rats with neuropathic or inflammatory pain.
  2. NIDD gene expression may be involved in the different pathological conditions including nerve regeneration, neuron loss or survival, and even pain processes.
    Title: Effect of peripheral axotomy on gene expression of NIDD in rat neural tissues.
  3. These results suggest that NIDD plays an important role in the regulation of the nitric oxide signaling pathway at postsynaptic sites through targeting of nueronal nitric oxide synthase to the postsynaptic membrane.
    Title: NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC23
Names
DHHC-23
NNOS-interacting DHHC domain-containing protein with dendritic mRNA
membrane-associated DHHC23 zinc finger protein
nNOS-intereacting DHHC-containing Dem protein-L
probable palmitoyltransferase ZDHHC23
zinc finger DHHC domain-containing protein 23
zinc finger, DHHC domain containing 23
zinc finger, DHHC-type containing 23
NP_998792.2
XP_008766960.1
XP_008766961.1
XP_008766962.1
XP_008766963.1
XP_038944469.1
XP_038944470.1
XP_063126742.1
XP_063126743.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213627.2 → NP_998792.2  palmitoyltransferase ZDHHC23

    See identical proteins and their annotated locations for NP_998792.2

    Status: PROVISIONAL

    Source sequence(s)
    AY886538
    UniProtKB/Swiss-Prot
    Q2TGI7, Q76IC6
    Conserved Domains (2) summary
    pfam01529
    Location:252 → 378
    zf-DHHC; DHHC palmitoyltransferase
    cl00989
    Location:102 → 185
    DUF420; Protein of unknown function (DUF420)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    70224581..70240971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270673.1 → XP_063126743.1  palmitoyltransferase ZDHHC23 isoform X5

  2. XM_008768740.4 → XP_008766962.1  palmitoyltransferase ZDHHC23 isoform X2

    See identical proteins and their annotated locations for XP_008766962.1

    UniProtKB/Swiss-Prot
    Q2TGI7, Q76IC6
    Conserved Domains (2) summary
    pfam01529
    Location:252 → 378
    zf-DHHC; DHHC palmitoyltransferase
    cl00989
    Location:102 → 185
    DUF420; Protein of unknown function (DUF420)

  3. XM_039088541.2 → XP_038944469.1  palmitoyltransferase ZDHHC23 isoform X1

    UniProtKB/TrEMBL
    A0A8L2RE80
    Conserved Domains (1) summary
    pfam01529
    Location:252 → 404
    DHHC; DHHC palmitoyltransferase

  4. XM_008768738.4 → XP_008766960.1  palmitoyltransferase ZDHHC23 isoform X1

    UniProtKB/TrEMBL
    A0A8L2RE80
    Related
    ENSRNOP00000076233.2, ENSRNOT00000093325.3
    Conserved Domains (1) summary
    pfam01529
    Location:252 → 404
    DHHC; DHHC palmitoyltransferase

  5. XM_039088542.2 → XP_038944470.1  palmitoyltransferase ZDHHC23 isoform X4

    Conserved Domains (2) summary
    pfam01529
    Location:252 → 341
    DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:102 → 178
    MerC; MerC mercury resistance protein

  6. XM_008768741.4 → XP_008766963.1  palmitoyltransferase ZDHHC23 isoform X3

    Conserved Domains (2) summary
    pfam01529
    Location:252 → 375
    zf-DHHC; DHHC palmitoyltransferase
    cl00989
    Location:102 → 185
    DUF420; Protein of unknown function (DUF420)

  7. XM_063270672.1 → XP_063126742.1  palmitoyltransferase ZDHHC23 isoform X2

    UniProtKB/Swiss-Prot
    Q2TGI7, Q76IC6

  8. XM_008768739.4 → XP_008766961.1  palmitoyltransferase ZDHHC23 isoform X2

    See identical proteins and their annotated locations for XP_008766961.1

    UniProtKB/Swiss-Prot
    Q2TGI7, Q76IC6
    Conserved Domains (2) summary
    pfam01529
    Location:252 → 378
    zf-DHHC; DHHC palmitoyltransferase
    cl00989
    Location:102 → 185
    DUF420; Protein of unknown function (DUF420)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76IC6.2 GenPept UniProtKB/Swiss-Prot:Q76IC6

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