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Xxylt1 xyloside xylosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363799, updated on 17-Aug-2024

Summary

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Official Symbol
Xxylt1provided by RGD
Official Full Name
xyloside xylosyltransferase 1provided by RGD
Primary source
RGD:1308154
See related
EnsemblRapid:ENSRNOG00000001729 AllianceGenome:RGD:1308154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308154
Summary
Predicted to enable magnesium ion binding activity; manganese ion binding activity; and xylosyl alpha-1,3-xylosyltransferase activity. Predicted to be involved in O-glycan processing. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human XXYLT1 (xyloside xylosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 65.0), Kidney (RPKM 62.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (83163432..83295879)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (69658481..69790938)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (73198404..73330682)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481096 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 Neighboring gene uncharacterized LOC120095678 Neighboring gene uncharacterized LOC120095677 Neighboring gene uncharacterized LOC102553680 Neighboring gene uncharacterized LOC134481012

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Detection of UDP-D-xylose: alpha-D-xyloside alpha 1-->3xylosyltransferase activity in human hepatoma cell line HepG2. Minamida S, et al. J Biochem, 1996 Nov. PMID 8982869
  2. Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch. Sethi MK, et al. J Biol Chem, 2012 Jan 20. PMID 22117070, Free PMC Article
  3. Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. Yu H, et al. Nat Chem Biol, 2015 Nov. PMID 26414444, Free PMC Article
  4. Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. Pandey A, et al. Glycobiology, 2018 Nov 1. PMID 30169771, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-xylosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables xylosyl alpha-1,3-xylosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xylosyl alpha-1,3-xylosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in O-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in O-glycan processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
xyloside xylosyltransferase 1
XP_063127010.1
XP_344028.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430794.1 → NP_001417723.1  xyloside xylosyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    D4ADL7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    83163432..83295879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_344027.10 → XP_344028.5  xyloside xylosyltransferase 1 isoform X1

    Related
    ENSRNOP00000002356.5, ENSRNOT00000002356.7

  2. XM_063270940.1 → XP_063127010.1  xyloside xylosyltransferase 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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