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Myl2 myosin light chain 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363925, updated on 2-Nov-2024

Summary

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Official Symbol
Myl2provided by RGD
Official Full Name
myosin light chain 2provided by RGD
Primary source
RGD:1564245
See related
EnsemblRapid:ENSRNOG00000030848 AllianceGenome:RGD:1564245
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mlc2; Mlc-2; MLC-2s/v
Summary
Predicted to enable actin monomer binding activity and calcium ion binding activity. Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction; cell growth involved in cardiac muscle cell development; and regulation of the force of heart contraction. Located in myofibril. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 10. Orthologous to human MYL2 (myosin light chain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 31563.8) See more
Orthologs
human mouse all
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Genomic context

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See Myl2 in Genome Data Viewer
Location:
12q16
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40114964..40126236, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34454223..34468554, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39951863..39959065, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095977 Neighboring gene 5S ribosomal RNA Neighboring gene coiled-coil domain containing 63 Neighboring gene uncharacterized LOC120095979 Neighboring gene cut-like homeobox 2 Neighboring gene uncharacterized LOC120095978

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure, organization, and expression of the rat cardiac myosin light chain-2 gene. Identification of a 250-base pair fragment which confers cardiac-specific expression. Henderson SA, et al. J Biol Chem, 1989 Oct 25. PMID 2808370
  2. Effects of calmodulin and okadaic acid on myofibrillar Ca2+ sensitivity in cardiac myocytes. Suematsu N, et al. Basic Res Cardiol, 2002 Mar. PMID 12002261
  3. Basal myosin light chain phosphorylation is a determinant of Ca2+ sensitivity of force and activation dependence of the kinetics of myocardial force development. Olsson MC, et al. Am J Physiol Heart Circ Physiol, 2004 Dec. PMID 15331360
  4. Heart myosin light chain 2 gene. Nucleotide sequence of full length cDNA and expression in normal and hypertensive rat. Kumar CC, et al. J Biol Chem, 1986 Feb 25. PMID 3005270
  5. [Expression of the MYL2 gene in the development of rat testis tissue]. Han L, et al. Zhonghua Nan Ke Xue, 2018 Mar. PMID 30161304

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death.
    Title: Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death.
  2. The MYL2 gene may be involved in the proliferation of spermatogonial stem cells and the process of sperm cells developing into mature sperm.
    Title: [Expression of the MYL2 gene in the development of rat testis tissue].
  3. Silencing MLCII by RNA interference reduced ALP activity (P<0.01), and eliminated RUNX2 mRNA expression (P<0.01). Addition of the MLC kinase inhibitor, ML7, reduced the CUCSassociated upregulation of RUNX2 expression (P<0.01) and ALP activity (P<0.01).
    Title: Cyclical compressive stress induces differentiation of rat primary mandibular condylar chondrocytes through phosphorylated myosin light chain II.
  4. nuclear MYL2 plays an important role in IR injury by transcriptionally upregulating NOX2 expression to enhance oxidative stress in a phosphorylation-dependent manner.
    Title: Nuclear cardiac myosin light chain 2 modulates NADPH oxidase 2 expression in myocardium: a novel function beyond muscle contraction.
  5. We have identified three protein biomarkers (GSN, MYL2, and VIM) that have potential utility in diagnosing the severity of Chagas disease
    Title: Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.
  6. Prostanoid F receptor (FPR) signalling mechanism(s) regulating myosin light chain-2 phosphorylation likely extend beyond those classically established for G(q/11)-coupled receptors.
    Title: Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of muscle ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiac muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac myofibril assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cell growth involved in cardiac muscle cell development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within heart contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in heart contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscle cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within muscle cell fate specification ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of the force of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of the force of heart contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in A band IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cardiac myofibril ISO
Inferred from Sequence Orthology
more info
  
located_in contractile muscle fiber IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Names
cardiac myosin light chain-2
myosin, light chain 2, regulatory, cardiac, slow
myosin, light polypeptide 2, regulatory, cardiac, slow

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035252.2 → NP_001030329.2  myosin regulatory light chain 2, ventricular/cardiac muscle isoform

    See identical proteins and their annotated locations for NP_001030329.2

    Status: PROVISIONAL

    Source sequence(s)
    BC126064
    UniProtKB/Swiss-Prot
    A0JMZ7, P08733
    UniProtKB/TrEMBL
    A0A8I5Y0S1
    Related
    ENSRNOP00000076784.1, ENSRNOT00000095667.2
    Conserved Domains (1) summary
    COG5126
    Location:14 → 163
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    40114964..40126236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089640.2 → XP_038945568.1  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0S1
    Related
    ENSRNOP00000039707.7, ENSRNOT00000050368.7
    Conserved Domains (1) summary
    COG5126
    Location:1 → 144
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08733.2 GenPept UniProtKB/Swiss-Prot:P08733

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
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