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Aasdh aminoadipate-semialdehyde dehydrogenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 364136, updated on 10-Oct-2024

Summary

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Official Symbol
Aasdhprovided by RGD
Official Full Name
aminoadipate-semialdehyde dehydrogenaseprovided by RGD
Primary source
RGD:1311135
See related
EnsemblRapid:ENSRNOG00000002137 AllianceGenome:RGD:1311135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311135
Summary
Predicted to act upstream of or within amino acid activation for nonribosomal peptide biosynthetic process and beta-alanine metabolic process. Orthologous to human AASDH (aminoadipate-semialdehyde dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 54.7), Spleen (RPKM 50.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aasdh in Genome Data Viewer
Location:
14p11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31609488..31636066)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31255019..31281802)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (33619990..33647268)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096737 Neighboring gene signal recognition particle 72 Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene uncharacterized LOC120096736 Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene ribosomal protein L23a, pseudogene 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Vertebrate Acyl CoA synthetase family member 4 (ACSF4-U26) is a β-alanine-activating enzyme homologous to bacterial non-ribosomal peptide synthetase. Drozak J, et al. FEBS J, 2014 Mar. PMID 24467666
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid activation for nonribosomal peptide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within amino acid activation for nonribosomal peptide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within beta-alanine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-alanine-activating enzyme
Names
acyl-CoA synthetase family member 4
NP_001385951.1
XP_038948856.1
XP_038948857.1
XP_038948859.1
XP_038948861.1
XP_038948862.1
XP_038948863.1
XP_038948864.1
XP_063129488.1
XP_063129489.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399022.1 → NP_001385951.1  beta-alanine-activating enzyme

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    D4A5F5
    Conserved Domains (4) summary
    COG1520
    Location:753 → 1048
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    sd00039
    Location:751 → 786
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:16 → 532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam13570
    Location:1059 → 1091
    PQQ_3; PQQ-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    31609488..31636066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092935.2 → XP_038948863.1  beta-alanine-activating enzyme isoform X4

    Conserved Domains (3) summary
    sd00039
    Location:751 → 786
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:16 → 532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam13360
    Location:791 → 971
    PQQ_2; PQQ-like domain

  2. XM_039092928.2 → XP_038948856.1  beta-alanine-activating enzyme isoform X1

    UniProtKB/TrEMBL
    D4A5F5
    Related
    ENSRNOP00000002907.5, ENSRNOT00000002907.7
    Conserved Domains (4) summary
    COG1520
    Location:753 → 1048
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    sd00039
    Location:751 → 786
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:16 → 532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam13570
    Location:1059 → 1091
    PQQ_3; PQQ-like domain

  3. XM_039092934.2 → XP_038948862.1  beta-alanine-activating enzyme isoform X3

    Conserved Domains (3) summary
    sd00039
    Location:751 → 786
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:16 → 532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam13360
    Location:791 → 973
    PQQ_2; PQQ-like domain

  4. XM_039092933.2 → XP_038948861.1  beta-alanine-activating enzyme isoform X2

    Related
    ENSRNOP00000108559.1, ENSRNOT00000144479.1
    Conserved Domains (4) summary
    COG1520
    Location:753 → 1029
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    sd00039
    Location:751 → 786
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:16 → 532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam13570
    Location:1015 → 1047
    PQQ_3; PQQ-like domain

  5. XM_039092936.2 → XP_038948864.1  beta-alanine-activating enzyme isoform X5

    Conserved Domains (3) summary
    COG1520
    Location:553 → 793
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    cd17654
    Location:16 → 528
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam01011
    Location:525 → 555
    PQQ; PQQ enzyme repeat

  6. XM_039092931.2 → XP_038948859.1  beta-alanine-activating enzyme isoform X1

    UniProtKB/TrEMBL
    D4A5F5
    Conserved Domains (4) summary
    COG1520
    Location:753 → 1048
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    sd00039
    Location:751 → 786
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:16 → 532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam13570
    Location:1059 → 1091
    PQQ_3; PQQ-like domain

  7. XM_039092929.1 → XP_038948857.1  beta-alanine-activating enzyme isoform X1

    UniProtKB/TrEMBL
    D4A5F5
    Conserved Domains (4) summary
    COG1520
    Location:753 → 1048
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    sd00039
    Location:751 → 786
    7WD40; WD40 repeat [structural motif]
    cd17654
    Location:16 → 532
    A_NRPS_acs4; acyl-CoA synthetase family member 4
    pfam13570
    Location:1059 → 1091
    PQQ_3; PQQ-like domain

  8. XM_063273419.1 → XP_063129489.1  beta-alanine-activating enzyme isoform X6

  9. XM_063273418.1 → XP_063129488.1  beta-alanine-activating enzyme isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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