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Plek pleckstrin [ Rattus norvegicus (Norway rat) ]

Gene ID: 364206, updated on 2-Nov-2024

Summary

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Official Symbol
Plekprovided by RGD
Official Full Name
pleckstrinprovided by RGD
Primary source
RGD:1308269
See related
EnsemblRapid:ENSRNOG00000005214 AllianceGenome:RGD:1308269
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; exocytosis; and positive regulation of cellular component organization. Predicted to be located in cytoplasm and ruffle membrane. Predicted to be active in plasma membrane. Orthologous to human PLEK (pleckstrin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 536.7), Lung (RPKM 107.4) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plek in Genome Data Viewer
Location:
14q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (95598650..95631326, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (91397015..91429693, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (100151518..100184192, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481789 Neighboring gene F-box protein 48 Neighboring gene uncharacterized LOC134481790 Neighboring gene uncharacterized LOC120096673 Neighboring gene cannabinoid receptor interacting protein 1 Neighboring gene protein phosphatase 3, regulatory subunit B, alpha Neighboring gene uncharacterized LOC134481791

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Lian L, et al. Blood, 2009 Apr 9. PMID 19190246, Free PMC Article
  2. Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin. Edlich C, et al. Structure, 2005 Feb. PMID 15698571
  3. Phosphorylated pleckstrin induces cell spreading via an integrin-dependent pathway. Roll RL, et al. J Cell Biol, 2000 Sep 18. PMID 10995449, Free PMC Article
  4. Pleckstrin induces cytoskeletal reorganization via a Rac-dependent pathway. Ma AD, et al. J Biol Chem, 1999 Oct 1. PMID 10497244
  5. Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain. Ma AD, et al. J Cell Biol, 1997 Mar 10. PMID 9060471, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112902

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell projection organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet aggregation IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet degranulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inositol-polyphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of integrin activation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of platelet activation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion by platelet IEA
Inferred from Electronic Annotation
more info
  
involved_in protein secretion by platelet ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell diameter ISO
Inferred from Sequence Orthology
more info
  
involved_in ruffle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in thrombin-activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in thrombin-activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking involved in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking involved in exocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025750.1 → NP_001020921.1  pleckstrin

    See identical proteins and their annotated locations for NP_001020921.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098846
    UniProtKB/Swiss-Prot
    Q4KM33
    UniProtKB/TrEMBL
    A0A8I6ANN0, A6JPY3
    Related
    ENSRNOP00000007044.3, ENSRNOT00000007044.7
    Conserved Domains (4) summary
    cd04445
    Location:125 → 223
    DEP_PLEK1; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, ...
    cd13301
    Location:3 → 110
    PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1
    cd13302
    Location:239 → 346
    PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:6 → 101
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    95598650..95631326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251520.1 → XP_006251582.1  pleckstrin isoform X1

    See identical proteins and their annotated locations for XP_006251582.1

    UniProtKB/Swiss-Prot
    Q4KM33
    UniProtKB/TrEMBL
    A0A8I6ANN0, A6JPY3
    Related
    ENSRNOP00000083092.2, ENSRNOT00000094345.2
    Conserved Domains (4) summary
    cd04445
    Location:125 → 223
    DEP_PLEK1; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, ...
    cd13301
    Location:3 → 110
    PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1
    cd13302
    Location:239 → 346
    PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:6 → 101
    PH; PH domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KM33.1 GenPept UniProtKB/Swiss-Prot:Q4KM33

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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