Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pip4p1provided by RGD
Official Full Name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1provided by RGD
Primary source: RGD:1307475
See related: EnsemblRapid:ENSRNOG00000009948 AllianceGenome:RGD:1307475
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem55b; RGD1307475
Summary: Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Predicted to be involved in several processes, including phosphatidylinositol dephosphorylation; positive regulation of TORC1 signaling; and proton-transporting V-type ATPase complex assembly. Predicted to be active in bounding membrane of organelle and plasma membrane. Orthologous to human PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 97.8), Brain (RPKM 84.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (26620399..26624369, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24146854..24150739, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (27852152..27855999, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH94450 (e-PCR)
- UniSTS:119698

RH140031 (e-PCR)
- UniSTS:222113

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton-transporting V-type ATPase complex assembly	ISO Inferred from Sequence Orthology more info
involved_in proton-transporting V-type ATPase complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to sterol depletion	ISO Inferred from Sequence Orthology more info
involved_in response to sterol depletion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in phagocytic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Names: PtdIns-4,5-P(2) 4-phosphatase type I; ptdIns-4,5-P2 4-Ptase I; transmembrane protein 55B; transmembrane protein 55B-like; type 1 PtdIns-4,5-P2 4-Ptase; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase

NP_001014255.1

EC 3.1.3.78

XP_006251950.1

EC 3.1.3.78

XP_006251951.1

EC 3.1.3.78

XP_017455249.1

EC 3.1.3.78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014233.2 → NP_001014255.1 type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

See identical proteins and their annotated locations for NP_001014255.1

Status: PROVISIONAL

Source sequence(s)

BC087604

UniProtKB/Swiss-Prot

Q5PPM8

UniProtKB/TrEMBL

A6KEC3

Related

ENSRNOP00000013225.5, ENSRNOT00000013225.8

Conserved Domains (1) summary

pfam09788
Location:4 → 277

Tmemb_55A; Transmembrane protein 55A

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

26620399..26624369 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251888.4 → XP_006251950.1 type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1

Conserved Domains (1) summary

pfam09788
Location:4 → 270

Tmemb_55A; Transmembrane protein 55A
XM_017599760.3 → XP_017455249.1 type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X3
XM_006251889.5 → XP_006251951.1 type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X2

UniProtKB/TrEMBL

A0A8I6GLH6

Related

ENSRNOP00000096185.1, ENSRNOT00000115002.2

Conserved Domains (1) summary

pfam09788
Location:4 → 154

Tmemb_55A; Transmembrane protein 55A