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SSA2 Hsp70 family chaperone [ Candida albicans SC5314 ]

Gene ID: 3644711, updated on 30-Nov-2023

Summary

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Gene symbol
SSA2
Gene description
Hsp70 family chaperone
Locus tag
CAALFM_C104300CA
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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Genomic context

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See SSA2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
1
Sequence:
Chromosome: 1; NC_032089.1 (890373..892310, complement)

Chromosome 1 - NC_032089.1Genomic Context describing neighboring genes Neighboring gene GPI-anchor transamidase Neighboring gene acetate--CoA ligase Neighboring gene Gig1p Neighboring gene Gpm2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_032089.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Uptake of the antifungal cationic peptide Histatin 5 by Candida albicans Ssa2p requires binding to non-conventional sites within the ATPase domain. Sun JN, et al. Mol Microbiol, 2008 Dec. PMID 19006817, Free PMC Article
  2. Candida albicans cell wall ssa proteins bind and facilitate import of salivary histatin 5 required for toxicity. Li XS, et al. J Biol Chem, 2006 Aug 11. PMID 16720580
  3. Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2. Xie JL, et al. Microb Cell, 2017 Oct 2. PMID 29082232, Free PMC Article
  4. Characterization of a novel separase-interacting protein and candidate new securin, Eip1p, in the fungal pathogen Candida albicans. Sparapani S, et al. Mol Biol Cell, 2019 Sep 1. PMID 31411946, Free PMC Article
  5. Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans. Alkafeef SS, et al. PLoS Genet, 2018 Jan. PMID 29337983, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ssa2p binds Hst 5 at a surface-localized epitope in a subunit of the ATPase domain.
    Title: Uptake of the antifungal cationic peptide Histatin 5 by Candida albicans Ssa2p requires binding to non-conventional sites within the ATPase domain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables misfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chaperone cofactor-dependent protein refolding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein refolding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Hsp70 family chaperone
XP_713669.2
  • HSP70 family chaperone; cell wall fractions; antigenic; beta-defensin peptides impport; ATPase domain binds histatin 5; at hyphal surface, not yeast; farnesol-repressed in biofilm; flow model, Spider biofilm repressed; caspofungin repressed

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_032089.1 Reference assembly

    Range
    890373..892310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_708576.2 → XP_713669.2  Hsp70 family chaperone [Candida albicans SC5314]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A1D8PD89, P46587, Q59VM8
    UniProtKB/TrEMBL
    A0A8H6BSJ4, A0A8H6C0U1, C4YEK6
    Conserved Domains (1) summary
    PTZ00009
    Location:4 → 645
    PTZ00009; heat shock 70 kDa protein; Provisional
Nucleotide Protein
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