U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Micu3 mitochondrial calcium uptake family, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364601, updated on 10-Jul-2024

Summary

Go to the top of the page Help
Official Symbol
Micu3provided by RGD
Official Full Name
mitochondrial calcium uptake family, member 3provided by RGD
Primary source
RGD:1563411
See related
EnsemblRapid:ENSRNOG00000012767 AllianceGenome:RGD:1563411
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Efha2
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to be part of uniplex complex. Orthologous to human MICU3 (mitochondrial calcium uptake family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 191.6), Kidney (RPKM 38.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Micu3 in Genome Data Viewer
Location:
16q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (58624702..58714302, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51919859..52010705, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (55043051..55133080, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene zinc finger DHHC-type palmitoyltransferase 2 Neighboring gene fibroblast growth factor 20 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats. Wang J, et al. Exp Neurol, 2023 Mar. PMID 36549422
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats.
    Title: Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion sensor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion sensor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium import into the mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium import into the mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_positive_effect positive regulation of neurotransmitter secretion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of uniplex complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
calcium uptake protein 3, mitochondrial
Names
EF hand domain family, member A2
EF-hand domain-containing family member A2
mitochondrial uptake family, member 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191892.1 → NP_001178821.1  calcium uptake protein 3, mitochondrial

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    D3ZG95
    Related
    ENSRNOP00000017025.6, ENSRNOT00000017025.9
    Conserved Domains (3) summary
    pfam05763
    Location:325 → 413
    DUF835; Protein of unknown function (DUF835)
    pfam13499
    Location:421 → 468
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:418 → 471
    EF-hand_8; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    58624702..58714302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094721.2 → XP_038950649.1  calcium uptake protein 3, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZTV9
    Related
    ENSRNOP00000082387.1, ENSRNOT00000102161.2
    Conserved Domains (1) summary
    cd16175
    Location:229 → 459
    EFh_MICU3; EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins

  2. XM_008771293.4 → XP_008769515.1  calcium uptake protein 3, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I6AA12
    Related
    ENSRNOP00000088716.1, ENSRNOT00000099337.2
    Conserved Domains (2) summary
    PTZ00183
    Location:231 → 346
    PTZ00183; centrin; Provisional
    pfam13833
    Location:429 → 482
    EF-hand_8; EF-hand domain pair

  3. XM_006253200.5 → XP_006253262.1  calcium uptake protein 3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6A2H6
    Related
    ENSRNOP00000087041.1, ENSRNOT00000098345.2
    Conserved Domains (1) summary
    pfam13833
    Location:442 → 495
    EF-hand_8; EF-hand domain pair

  4. XM_063275597.1 → XP_063131667.1  calcium uptake protein 3, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A6JPW1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous