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Shcbp1 SHC binding and spindle associated 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364648, updated on 2-Nov-2024

Summary

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Official Symbol
Shcbp1provided by RGD
Official Full Name
SHC binding and spindle associated 1provided by RGD
Primary source
RGD:1590844
See related
EnsemblRapid:ENSRNOG00000053026 AllianceGenome:RGD:1590844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SH2 domain binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway and regulation of neural precursor cell proliferation. Predicted to be located in cytoplasm and spindle. Orthologous to human SHCBP1 (SHC binding and spindle associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 73.5), Testes (RPKM 63.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Shcbp1 in Genome Data Viewer
Location:
16q12.5
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (91373843..91405409)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (84672277..84703843)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (90613826..90642683)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 2, pseudogene 5 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. Schmandt R, et al. Oncogene, 1999 Mar 11. PMID 10086341
  2. The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Chen J, et al. Genes Dev, 2012 Apr 15. PMID 22508726, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SHC SH2 domain-binding protein 1
Names
Shc SH2-domain binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399215.1 → NP_001386144.1  SHC SH2 domain-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A0G2K2J0
    Related
    ENSRNOP00000072261.2, ENSRNOT00000079334.3
    Conserved Domains (1) summary
    pfam13229
    Location:446 → 546
    Beta_helix; Right handed beta helix region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    91373843..91405409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095271.2 → XP_038951199.1  SHC SH2 domain-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZD8
    Related
    ENSRNOP00000083446.1, ENSRNOT00000094192.2
    Conserved Domains (1) summary
    pfam13229
    Location:403 → 527
    Beta_helix; Right handed beta helix region

RNA

  1. XR_005495150.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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